Finemappingof thehyperglycemicandobesityQTLbycongenic strains suggests multiple loci on rat chromosome 14
Finemappingof thehyperglycemicandobesityQTLbycongenic strains suggests multiple loci on rat chromosome 14
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通过同源品系对高血糖和肥胖 QTL 进行精细定位表明大鼠 14 号染色体上有多个位点
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Kozo Matsumoto
中科院分区：
文献类型：
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作者：
M. Akhi;H. Kose;Kozo Matsumoto
先前的连锁分析在利用2型糖尿病模型OLETF（Otsuka Long Evans德岛脂肪）大鼠的杂交中在大鼠14号染色体上鉴定了高血糖定量性状位点（QTL）Nidd 2/of。一项单独的QTL研究将肥胖QTL Obs 5定位到相同的染色体区域。一个同类菌株放置约。在F344背景上含有Nidd 2/of和Obs 5的38 cM OLETF衍生片段显示具有轻度糖尿病和肥胖表型，表明存在影响葡萄糖代谢和脂肪积累的突变。为了更精确地定位位点，我们产生了一系列缺失亚同源菌株，其中OLETF片段从两端缩短。我们发现在Nidd 2/of位点上至少存在两个高血糖QTL，推测它们位于Nidd 2/of区域的两端。而Obs 5 QTL则进一步缩小到了ca. 10 cM片段。J.医学投资52：109-113，二月，2005
Linkage analysis previously identified a hyperglycemic quantitativetrait locus (QTL), Nidd 2/of, on rat Chromosome 14 in crosses utilizing OLETF (Otsuka Long Evans Tokushima Fatty) rat, a model for type 2 diabetes. A separate QTL study mapped an obesity QTL, Obs5, to the same chromosomal region. A congenic strain placing ca. 38 cM OLETF-derived segments containing both Nidd2/of and Obs5 on the F344 background was shown to possess mild diabetic and obese phenotypes, suggesting the presence of mutations affecting the glucose metabolism and fat accumulation. In orderto localizethe loci moreprecisely,wegeneratedaseriesofdeletionsubcongenic strains in which OLETF-segments were shortened from either ends. We found that there are at least two hyperglycemic QTLs within the Nidd2/of locus.Wepredict that theyare localized towards both ends of the Nidd2/of region. In contrast, Obs5 QTL was further narrowed down to a single region of ca. 10 cM fragment. J. Med. Invest. 52 : 109-113, February, 2005
小鼠 2 号和 17 号染色体上的肥胖 QTL。
影响因子：
4.4
作者：
Taylor,BA;Phillips,SJ
通讯作者：
Phillips,SJ
多因素小鼠模型中控制体脂肪、脂蛋白代谢和胰岛素水平的基因位点。
DOI：
10.1172/jci1748
发表时间：
1998
期刊：
The Journal of clinical investigation
影响因子：
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作者：
Mehrabian,M;Wen,PZ;Fisler,J;Davis,RC;Lusis,AJ
通讯作者：
Lusis,AJ