The Influence of a High-Fat Dietary Environment in the Fetal Period on Postnatal Metabolic and Immune Function
The Influence of a High-Fat Dietary Environment in the Fetal Period on Postnatal Metabolic and Immune Function
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DOI：
10.1038/oby.2009.513
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发表时间：
2010-09-01
期刊：
影响因子：
6.9
通讯作者：
Sato, Kazuto
中科院分区：
文献类型：
--
作者：
Odaka, Yukino;Nakano, Mana;Sato, Kazuto
很少有报告表明胎儿期的高脂肪（HF）饮食环境是否会影响成熟期的免疫功能或生活方式相关疾病的发生。我们研究了胎儿期高频饮食环境对产后代谢和免疫功能的影响。从交配到分娩，总共 16 只怀孕小鼠被给予对照 (CON) 饮食，16 只被给予 HF 饮食。分娩后，哺乳期小鼠接受 CON 或 HF 饮食，分为四组。断奶后，子代小鼠的饮食与其母亲在哺乳期间所接受的饮食相同。产后的高频饮食摄入增加了脂肪垫重量、血糖和瘦素水平。胎儿期的高频饮食会导致脾淋巴细胞减少、胸腺皮质变薄以及抗原特异性免疫反应受损。此外，胎儿心力衰竭组的肿瘤坏死因子（TNF）-α 产生和血清甘油三酯水平升高。此外，HF-HF 组的卵清蛋白 (OVA) 特异性 IgG 持续下降，IgE 升高，这与肝脏的晚期脂肪变化相关。这项研究的结果表明，胎儿期的高频环境会诱发肥胖和免疫负担的表观遗传倾向，部分原因是脂肪组织量增加、免疫细胞数量显着减少和免疫细胞活性降低。
Few reports show whether a high-fat (HF) dietary environment in the fetal period affects immune function or the development of lifestyle-related disease at maturity. We examined the influence of an HF dietary environment in the fetal period on postnatal metabolic and immune function. A total of 16 pregnant mice were given control (CON) diet and 16 were given HF diet in the gestational period, from mating to delivery. After delivery lactating mice were given either CON or HF diet, resulting in four groups. After weaning, the offspring mice were given the same diet that their mothers received during lactation. HF dietary intake in the postnatal period increased fat pad weights, serum glucose, and leptin levels. An HF diet in the fetal period resulted in fewer splenic lymphocytes, a thinner thymic cortex, and impaired antigen-specific immune reactions. Furthermore, tumor necrosis factor (TNF)-alpha production and serum triglyceride levels were elevated in the fetal HF group. In addition, the HF-HF group showed a consistent decrease in ovalbumin (OVA)-specific IgG and elevation of IgE, associated with advanced fatty changes in the liver. Results from this study suggest that HF environment during the fetal period induces epigenetic propensity toward obesity and immunological burden in part due to increased adipose tissue mass, significant reduction in the number of immune cells and decreased activities of immune cells.