Topological braiding and virtual particles on the cell membrane
Topological braiding and virtual particles on the cell membrane
复制标题
DOI：
10.1073/pnas.2104191118
复制
发表时间：
2021-08-24
影响因子：
11.1
通讯作者：
Fakhri, Nikta
中科院分区：
文献类型：
--
作者：
Liu, Jinghui;Totz, Jan F.;Fakhri, Nikta
复杂物质场中拓扑结构的编织为信息编码和处理提供了一个强大的框架，在拓扑量子计算中得到了广泛的研究。在生命系统中，拓扑缺陷对生物化学信号波的定位和组织至关重要，但其编织动力学仍未被探索。在这里，我们发现在海星卵细胞膜上组织Rho-GTP蛋白信号动力学和力生成的螺旋波核经历了自发的编织动力学。实验测量的世界线编织指数和拓扑熵与细胞活动相关，并与一般场论的预测一致。我们的分析进一步揭示了在缺陷散射事件中虚拟准粒子激发的产生和湮灭，表明量子和生命物质之间的现象学相似。
Braiding of topological structures in complex matter fields provides a robust framework for encoding and processing information, and it has been extensively studied in the context of topological quantum computation. In living systems, topological defects are crucial for the localization and organization of biochemical signaling waves, but their braiding dynamics remain unexplored. Here, we show that the spiral wave cores, which organize the Rho-GTP protein signaling dynamics and force generation on the membrane of starfish egg cells, undergo spontaneous braiding dynamics. Experimentally measured world line braiding exponents and topological entropy correlate with cellular activity and agree with predictions from a generic field theory. Our analysis further reveals the creation and annihilation of virtual quasi-particle excitations during defect scattering events, suggesting phenomenological parallels between quantum and living matter.