INTRINSIC AND EXTRINSIC DETERMINANTS OF NEURONAL DEVELOPMENT - RELATION TO INFANTILE-AUTISM
INTRINSIC AND EXTRINSIC DETERMINANTS OF NEURONAL DEVELOPMENT - RELATION TO INFANTILE-AUTISM
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DOI：
10.1007/bf01531304
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发表时间：
1982-01-01
影响因子：
3.9
通讯作者：
ANDERS, TF
中科院分区：
文献类型：
--
作者：
CIARANELLO, RD;VANDENBERG, SR;ANDERS, TF
本文试图在大脑发育障碍的背景下看待自闭症综合征。作者回顾了一些已知的或怀疑的自闭症综合征的原因：母亲风疹，代谢疾病和遗传。概述了细胞神经解剖学和化学神经传递的一些基本原理。人类大脑发育的阶段，从神经形成到组织发生，细胞迁移，以及树突树和轴突投射的详细说明。作者的结论是，有有限数量的发育位点可能被破坏并导致自闭症综合征，并且这些最有可能发生在神经元发育的最后阶段，在迁移的神经元到达大脑中的最终位置并开始精心制作交流过程之后。最后，作者推测神经化学紊乱可能如何改变终末期神经元分化，导致婴儿自闭症的病理。
This paper attempts to view the autistic syndrome in the context of a disorder of brain development. The authors review some of the known or suspected causes of the autistic syndrome: maternal rubella, metabolic diseases, and heredity. Some basic principles of cellular neuroanatomy and chemical neurotransmission are sketched. The stages of human brain development from neurulation through histogenesis, cell migration, and elaboration of dendritic trees and axonal projections are described. The authors conclude that there are a limited number of developmental loci that could be disrupted and lead to the autistic syndrome, and that these most probably occur in the end stages of neuronal development, after the migrating neurons have reached their final place in the brain and have begun to elaborate communicative processes. Finally, the authors speculate on how neurochemical disturbances might alter end stage neuronal differentiation leading to the pathology of infantile autism.