Motor and Non-Motor Symptoms in Parkinson's Disease: Effects on Quality of Life
Motor and Non-Motor Symptoms in Parkinson's Disease: Effects on Quality of Life
复制标题
DOI：
10.5152/npa.2016.12758
复制
发表时间：
2017-06-01
影响因子：
1.1
通讯作者：
Asil, Talip
中科院分区：
文献类型：
--
作者：
Gokcal, Elif;Gur, Veysel Eren;Asil, Talip
简介：本研究旨在评估运动和非运动症状的特发性帕金森病（IPD）患者，并确定自我报告的影响，所有现有的症状对他们的生活质量（QoL.Methods）的社会人口学和临床特征，药物治疗，并修改Hoehn和Yahr（mH&Y）评分的无认知功能障碍的IPD患者进行了记录。对患者进行了一项调查，询问不同的运动和非运动症状。要求患者按数量对他们的症状进行评级，从对他们的QoL影响最大到影响最小。受试者被分为两组：患有IPD 5年的受试者（组2）。这些群体进行了比较，在社会人口学和临床特征，现有的症状，这些症状对他们的QoL.Results的影响：有63例患者在第1组和37例患者在第2组。在社会人口学特征或mH& Y评分方面，两组之间未发现统计学显著差异。这两组中最常见的运动症状是震颤和运动迟缓;同时，这两组中最常见的非运动症状是疼痛-痉挛、便秘和白天过度嗜睡（EDS）。同样，虽然所有患者中最严重干扰QoL的症状报告为震颤和运动迟缓，但最令人不安的非运动症状是频繁排尿/失禁，这是一种不太常见的症状。疼痛痉挛、便秘和EDS是最常见的非运动症状，是影响生活质量最小的症状。结论：运动症状决定IPD的生活质量已被广泛接受。然而，在疾病的所有阶段都可以看到非运动症状。非运动症状对IPD患者生活质量的影响仍然很大。因此，除了众所周知的运动症状外，在体格检查期间可能被忽略但可能深刻影响QoL的非运动症状应被质疑并适当治疗，以尽可能改善PD患者的QoL。
Introduction: This study aimed to evaluate motor and non-motor symptoms in idiopathic Parkinson's disease (IPD) patients and to determine the self-reported influence of all existing symptoms on their quality of life (QoL).Methods: The sociodemographic and clinical characteristics, medical treatments, and Modified Hoehn and Yahr (mH&Y) scores of IPD patients without cognitive impairment were recorded. A survey questioning different motor and non-motor symptoms was administered to the patients. The patients were asked to rate their symptoms by number from the greatest influence to the least influence on their QoL. Subjects were divided into two groups: those suffering from IPD for 5 years (Group 2). These groups were compared in terms of sociodemographic and clinical characteristics, existing symptoms, and influences of these symptoms on their QoL.Results: There were 63 patients in Group 1 and 37 patients in Group 2. No statistically significant differences were detected between the groups with respect to sociodemographic characteristics or mH& Y scores. The most common motor symptoms in both of these groups were tremor and bradykinesia; meanwhile, the non-motor symptoms most frequently encountered in these groups were pain-cramps, constipation, and excessive daytime sleepiness (EDS). Again, while the symptoms that most greatly disturbed QoL in all patients were reported to be tremor and bradykinesia, the most disturbing non-motor symptom was frequent voiding/incontinence, which was a less common symptom. Pain-cramp, constipation, and EDS, which were the most frequent non-motor symptoms, were the symptoms that least disturbed QoL.Conclusion: It is widely accepted that motor symptoms determine QoL in IPD. However, non-motor symptoms are seen during all phases of the disease. The impact of non-motor symptoms on the QoL of IPD patients remains substantial. Therefore, in addition to the well-known motor symptoms, non-motor symptoms, which may be overlooked during physical examination yet may profoundly impact QoL, should be questioned and treated appropriately to improve QoL in PD patients as much as possible.