Genomic data reject the hypothesis of a prosimian primate clade
Genomic data reject the hypothesis of a prosimian primate clade
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DOI：
10.1016/j.jhevol.2011.04.004
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发表时间：
2011-09-01
影响因子：
3.2
通讯作者：
Wildman, Derek E.
中科院分区：
文献类型：
--
作者：
Jameson, Natalie M.;Hou, Zhuo-Cheng;Wildman, Derek E.
眼镜猴的系统发育位置。一个多世纪以来，灵长类动物一直是一个备受争议的话题。尽管进行了大量的形态学和分子学研究，但将眼镜猴归为原猿分支中的链鼻灵长类动物或将类人猿归为单猿分支的证据并不充分。本文利用最近公布的菲律宾眼镜猴Tarsius syrichta全基因组序列，对其在灵长类目中的系统发育关系进行了推测。我们还提出了灵长类动物内部分化时间的估计。利用来自1078个同源基因的126万碱基对多序列比对，我们为单亲缘进化支的存在提供了压倒性的统计支持。我们还提出了用局部松弛分子钟方法估计散度日期。现存灵长类动物最近的共同祖先的时间估计在64.9 ~ 72.6 Ma之间，单plorrhines最近的共同祖先估计在58.9 ~ 68.6 Ma之间。对现存的三个主要灵长类分支的核苷酸取代率的研究表明，类人猿的取代率比链鼻虫或眼镜猴慢。我们的研究结果提供了一个框架，在更广泛的哺乳动物系统发育背景下，灵长类动物的形态、生殖和基因组特征可以被重建。(C) 2011 Elsevier Ltd.版权所有。
The phylogenetic position of tarsiers within the. primates has been a controversial subject for over a century. Despite numerous morphological and molecular studies, there has been weak support for grouping tarsiers with either strepsirrhine primates in a prosimian clade or with anthropoids in a haplorrhine clade. Here, we take advantage of the recently released whole genome assembly of the Philippine tarsier, Tarsius syrichta, in order to infer the phylogenetic relationship of Tarsius within the order Primates. We also present estimates of divergence times within the primates. Using a 1.26 million base pair multiple sequence alignment derived from 1078 orthologous genes, we provide overwhelming statistical support for the presence of a haplorrhine clade. We also present divergence date estimates using local relaxed molecular clock methods. The estimated time of the most recent common ancestor of extant Primates ranged from 64.9 Ma to 72.6 Ma, and haplorrhines were estimated to have a most recent common ancestor between 58.9 Ma and 68.6 Ma. Examination of rates of nucleotide substitution in the three major extant primate clades show that anthropoids have a slower substitution rate than either strepsirrhines or tarsiers. Our results provide the framework on which primate morphological, reproductive, and genomic features can be reconstructed in the broader context of mammalian phylogeny. (C) 2011 Elsevier Ltd. All rights reserved.