NFkB and Nrf2 in esophageal epithelial barrier function.
NFkB and Nrf2 in esophageal epithelial barrier function.
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DOI：
10.4161/tisb.27463
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发表时间：
2013-12-01
期刊：
影响因子：
3.1
通讯作者：
Chen XL
中科院分区：
文献类型：
--
作者：
Chen H;Fang Y;Li W;Orlando RC;Shaheen N;Chen XL
食管的复层鳞状上皮形成了一个紧密的保护屏障。屏障功能的缺陷导致胃食管反流病（GERD），其表现为由于暴露于胃肠道反流物而对食管上皮的损伤。本文就NFkB和Nrf2在食管上皮屏障功能中的作用作一综述。了解食管中的这些分子通路可能有助于我们制定治疗策略，以改善GERD患者的临床结局。
The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 in esophageal epithelial barrier function. Understanding these molecular pathways in the esophagus may help us develop therapeutic strategies to improve clinical outcomes in patients with GERD.