Loss of melatonin daily rhythmicity is asociated with delirium development in hospitalized older adults
Loss of melatonin daily rhythmicity is asociated with delirium development in hospitalized older adults
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DOI：
10.1016/j.slsci.2016.08.001
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发表时间：
2016-10-01
期刊：
影响因子：
1.6
通讯作者：
Escobar, Carolina
中科院分区：
文献类型：
--
作者：
Angeles-Castellanos, Manuel;Ramirez-Gonzalez, Fatima;Escobar, Carolina
精神错乱与昼夜节律紊乱有关。在这项研究中，我们探讨了褪黑激素的昼夜节律变化是否是精神错乱的指标。褪黑素水平从入院的第一天到神志不清发作后的三天被测定。没有出现妄想症的患者表现出每天的褪黑素节律，而在出现妄想症的患者中，褪黑素节律丧失，平均褪黑素水平早在确诊为妄想症的前三天就下降了，这表明在到达医院时，昼夜节律褪黑素紊乱可以作为妄想症的一个指标。(C)2016年巴西睡眠协会。爱思唯尔B.V.制作和主办。
Delirium is associated with circadian rhythm disruption. In this study we have explored whether circadian variation of melatonin is an indicator for delirium. Melatonin levels were determined from the first day of hospitalization and up to three days after the onset of delirium. Patients who did not developed delirium exhibited a daily melatonin rhythm, while in patients that developed delirium, the melatonin rhythm was lost and mean melatonin levels were found decreased as early as three days before the diagnosis of delirium, indicating that on arrival to the hospital circadian melatonin disruption can be used as an indicator of delirium. (C) 2016 Brazilian Association of Sleep. Production and Hosting by Elsevier B.V.