Transmission of Staphylococcus aureus from Humans to Green Monkeys in The Gambia as Revealed by Whole-Genome Sequencing
Transmission of Staphylococcus aureus from Humans to Green Monkeys in The Gambia as Revealed by Whole-Genome Sequencing
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DOI：
10.1128/aem.01496-16
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Antonio, Martin
中科院分区：
文献类型：
--
作者：
Senghore, Madikay;Bayliss, Sion C.;Antonio, Martin
金黄色葡萄球菌是人类和动物的重要病原体。我们对来自冈比亚的90株金黄色葡萄球菌进行了基因组测序：46株来自人类侵袭性疾病的分离株，13株来自人类携带的分离株，31株来自猴携带的分离株。我们推断在冈比亚，金黄色葡萄球菌在不同的时间尺度上从人类传播到绿猴（绿猴）。我们报告了一种新的与猴子相关的金黄色葡萄球菌分支，它出现在估计发生在2700年前的人类到猴子的转换中。这一谱系对猴宿主的适应伴随着噬菌体携带基因的丧失，这些基因在人类定居中起着重要作用。我们还报道了最近具有良好特征的人类谱系序列6型（ST6）和ST15型在猴子之间的人传传播，这可能是因为人类对猴子栖息地的入侵不断增加。虽然我们没有发现从猴子向人类传播金黄色葡萄球菌的证据，但随着这两个物种的接触越来越密切，潜在病原体在物种间交流的风险可能会增加。
Staphylococcus aureus is an important pathogen of humans and animals. We genome sequenced 90 S. aureus isolates from The Gambia: 46 isolates from invasive disease in humans, 13 human carriage isolates, and 31 monkey carriage isolates. We inferred multiple anthroponotic transmissions of S. aureus from humans to green monkeys (Chlorocebus sabaeus) in The Gambia over different time scales. We report a novel monkey-associated clade of S. aureus that emerged from a human-to-monkey switch estimated to have occurred 2,700 years ago. Adaptation of this lineage to the monkey host is accompanied by the loss of phage-carrying genes that are known to play an important role in human colonization. We also report recent anthroponotic transmission of the well-characterized human lineages sequence type 6 (ST6) and ST15 to monkeys, probably because of steadily increasing encroachment of humans into the monkeys' habitat. Although we have found no evidence of transmission of S. aureus from monkeys to humans, as the two species come into ever-closer contact, there might be an increased risk of additional interspecies exchanges of potential pathogens.