USE OF DIMETHYLDIOXIRANE IN THE PREPARATION OF EPOXY DERIVATIVES RELATED TO INSECT JUVENILE HORMONES
USE OF DIMETHYLDIOXIRANE IN THE PREPARATION OF EPOXY DERIVATIVES RELATED TO INSECT JUVENILE HORMONES
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DOI：
10.1016/s0040-4020(01)86386-9
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发表时间：
1991-02-11
期刊：
影响因子：
2.1
通讯作者：
HAMMOCK, BD
中科院分区：
文献类型：
--
作者：
MESSEGUER, A;SANCHEZBAEZA, F;HAMMOCK, BD
对金合欢酸甲酯的环氧化反应进行了研究。 此外，二甲基二环氧乙烷已被证明是合成保幼激素III的推定代谢物（如二环氧化物4、三环氧化物5和环氧二醇7）的方便试剂。 该试剂也显示出是用于进行氚标记的衍生物4和7的制备的极好工具。 最后，顺式和反式四氢呋喃衍生物8a和8b，环氧二醇7的酸或酶水解产生的化合物的表征的分子力学和NMR研究，也有报道。
A study on the epoxidation of methyl farnesoate using the title reagent has been carried out. In addition, dimethyldioxirane has shown to be a convenient reagent for the synthesis of putative metabolites of juvenile hormone III, such as diepoxide 4, triepoxide 5 and epoxy diol 7. This reagent has also shown to be an excellent tool for performing the preparation of tritium labelled derivatives 4 and 7. Finally, molecular mechanics and NMR studies for the characterisation of cis and trans tetrahydrofuran derivatives 8a and 8b, compounds resulting from the acid or enzymatic hydrolysis of epoxy diol 7, are also reported.