Organocatalytic enantioselective Diels-Alder reaction of dienes with α-(N,N-diacylamino)acroleins
Organocatalytic enantioselective Diels-Alder reaction of dienes with α-(N,N-diacylamino)acroleins
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DOI：
10.1021/ol8011277
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发表时间：
2008-07-03
期刊：
影响因子：
5.2
通讯作者：
Akakura, Matsujiro
中科院分区：
文献类型：
--
作者：
Ishihara, Kazuaki;Nakano, Kazuhiko;Akakura, Matsujiro
环状和无环二烯与α-邻苯二甲酰亚胺基丙烯醛的催化和高对映选择性的狄尔斯-阿尔德反应提供环状α-季α-氨基酸前体。H-L-Phe-L-Leu-N（CH_2CH_2）（2）-还原三胺与五氟苯磺酸的构象柔性手性铵盐作为不对称Diels-Alder反应的催化剂是非常有效的。
Catalytic and highly enantioselective Diels-Alder reaction of cyclic and acyclic dienes with alpha-phthalimidoacroleins provides cyclic alpha-quaternary alpha-amino acid precursors. The conformationally flexible chiral ammonium salt of H-L-Phe-L-Leu-N(CH2CH2)(2)-reduced triamine with pentafluorobenzensulfonic acid is very effective as an asymmetric catalyst for the Diels-Alder reaction.