Optimization of Antibacterial Efficacy of Noble-Metal-Based Core-Shell Nanostructures and Effect of Natural Organic Matter
Optimization of Antibacterial Efficacy of Noble-Metal-Based Core-Shell Nanostructures and Effect of Natural Organic Matter
复制标题
贵金属基核壳纳米结构抗菌功效优化及天然有机物作用
DOI：
10.1021/acsnano.9b04366
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发表时间：
2019-11-01
期刊：
影响因子：
17.1
通讯作者：
Ge, Cuicui
中科院分区：
文献类型：
--
作者：
Cai, Tingting;Fang, Ge;Ge, Cuicui
由毒性较小的金属制成的贵金属基纳米材料因其独特的类似氧化物酶的活性而被用作潜在的抗菌剂。在本研究中，我们用超薄的壳层制备了具有核壳结构的PdpIr双金属纳米材料。Pd@Ir纳米结构具有形态依赖的杀菌活性，其中具有较高类氧化酶活性的Pd@Ir八面体具有比Pd@Ir立方体更强的杀菌活性。此外，我们的结果还表明，天然有机物的存在会影响纳米材料的抗菌行为。当与腐植酸(HA)相互作用时，Pd@Ir纳米结构诱导了较高水平的活性氧物种，从而显著增强了纳米结构的杀菌活性。机理分析表明，HA的存在有效地增强了纳米材料的类氧化物酶活性，促进了纳米材料的细胞内化。我们相信，本研究不仅将为提高贵金属基纳米材料的杀菌活性提供一种有效的策略，而且将为了解纳米材料在自然环境中的抗菌行为提供参考。
Noble -metal-based nanomaterials made of less toxic metals have been utilized as potential antibacterial agents due to their distinctive oxidase-like activity. In this study, we fabricated core-shell structured PdpIr bimetallic nanomaterials with an ultrathin shell. Pd@Ir nanostructures show morphology-dependent bactericidal activity, in which Pd@Ir octahedra possessing higher oxidase-like activity exert bactericidal activity stronger than that of Pd@Ir cubes. Furthermore, our results reveal that the presence of natural organic matter influences the antibacterial behaviors of nanomaterials. Upon interaction with humic acid (HA), the Pd@Ir nanostructures induce an elevated level of reactive oxygen species, resulting in significantly enhanced bactericidal activity of the nanostructures. Mechanism analysis shows that the presence of HA efficiently enhances the oxidase-like activity of nanomaterials and promotes the cellular internalization of nanomaterials. We believe that the present study will not only demonstrate an effective strategy for improving the bactericidal activity of noble-metal-based nanomaterials but also provide an understanding of the antibacterial behavior of nanomaterials in the natural environment.