JNK-induced apoptosis, compensatory growth, and cancer stem cells.
JNK-induced apoptosis, compensatory growth, and cancer stem cells.
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DOI：
10.1158/0008-5472.can-11-1982
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发表时间：
2012-01-15
期刊：
影响因子：
11.2
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Chen F
大量证据表明，JNKs是一组关键的应激反应蛋白，介导细胞凋亡，而细胞凋亡是肿瘤抑制的重要过程。然而，JNKs也参与了细胞的恶性转化和肿瘤的发生。本文试图将JNKs的这两个相互矛盾的功能与JNKs在邻近细胞和干细胞的代偿生长中的作用的最新发现联系起来，这可能为JNKs在调节癌症干细胞和癌症发病机制中的作用提供新的机制理解。
Overwhelming evidence suggests that the JNKs are a set of key stress responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, the JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these two contradictory functions of the JNKs with the recent discoveries on the role of the JNKs in the compensatory growth of the neighboring cells and stem cells, which may provide new mechanistic understanding on the role of the JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.