Increased involvement of the parahippocampal gyri in a sad mood predicts future depressive symptoms
Increased involvement of the parahippocampal gyri in a sad mood predicts future depressive symptoms
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DOI：
10.1093/scan/nsu006
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发表时间：
2014-12-01
影响因子：
4.2
通讯作者：
Kirsch, Peter
中科院分区：
文献类型：
--
作者：
Zamoscik, Vera;Huffziger, Silke;Kirsch, Peter
行为研究表明自传体记忆、沉思和抑郁之间存在关系。本研究的目的是确定是否缓解抑郁症患者表现出改变后扣带回皮质（PCC，在默认模式网络的节点）与海马旁回（PHG，与自传体记忆相关的区域）的连接，同时集中回忆负面记忆，这是否与日常生活症状和抑郁症的进一步过程。在功能性磁共振成像中，以个人负性生活事件为关键词，对29例缓解期抑郁症患者和29例匹配的健康对照者进行悲伤情绪诱导。此外，还进行了情绪和反刍的日常生活评估以及6个月的随访。缓解抑郁的参与者表现出比健康对照组更强的PCC与PHG的连接性，这在先前发作更多的患者中甚至更强。此外，PCC-PHG连接增加的患者在日常生活中表现出更悲伤的情绪和更多的反刍，并且在随访期间反刍和抑郁评分恶化。负性自传体记忆加工、沉思、悲伤情绪和抑郁在神经水平上的关系似乎是可能的。所确定的连接性增加可能表明复发性抑郁症的“疤痕”，并可能代表未来抑郁症的预后因素。
Behavioral studies suggest a relationship between autobiographical memory, rumination and depression. The objective of this study was to determine whether remitted depressed patients show alterations in connectivity of the posterior cingulate cortex (PCC, a node in the default mode network) with the parahippocampal gyri (PHG, a region associated with autobiographical memory) while intensively recalling negative memories and whether this is related to daily life symptoms and to the further course of depression. Sad mood was induced with keywords of personal negative life events in participants with remitted depression (n = 29) and matched healthy controls (n = 29) during functional magnetic resonance imaging. Additionally, daily life assessments of mood and rumination and a 6-month follow-up were conducted. Remitted depressed participants showed greater connectivity than healthy controls of the PCC with the PHG, which was even stronger in patients with more previous episodes. Furthermore, patients with increased PCC-PHG connectivity showed a sadder mood and more rumination in daily life and a worsening of rumination and depression scores during follow-up. A relationship of negative autobiographical memory processing, rumination, sad mood and depression on a neural level seems likely. The identified increased connectivity probably indicates a 'scar' of recurrent depression and may represent a prognostic factor for future depression.