Neocortical Association Cell Types in the Forebrain of Birds and Alligators
Neocortical Association Cell Types in the Forebrain of Birds and Alligators
复制标题
DOI：
10.1016/j.cub.2018.01.036
复制
发表时间：
2018-03-05
期刊：
影响因子：
9.2
通讯作者：
Ragsdale, Clifton W.
中科院分区：
文献类型：
--
作者：
Briscoe, Steven D.;Albertin, Caroline B.;Ragsdale, Clifton W.
鸟类端脑背侧有两个巨大的区域，巢皮质和中皮质，这两个区域都被证明对更高的认知功能有很大的贡献。从它们的联系来看，这些区域被认为相当于哺乳动物的新皮层第2层和第3层，各种新皮层联合区，或杏仁核，但这些是否是类比或同源的血统是未知的。我们用RNA-seq研究了中皮层和巢皮层的分子谱。基因表达实验表明，mesopallium，但不是nidopallium，共享一个转录因子网络与端脑内类的新皮质神经元，这是发现在新皮质层2，3，5，和6。短吻鳄的实验表明，这些神经元也丰富的鳄鱼皮质，并形成一个大的mesopallium样结构的背侧脑室脊。与以前的工作一起，这些分子研究结果表明，同源性下降的鸟类端脑背侧的神经元细胞类型与哺乳动物新皮层电路的主要兴奋性细胞类型：第4层输入神经元，深层输出神经元，和多层intratelencephalic协会神经元。这些数据提出了一种有趣的可能性，即鸟类和灵长类动物的谱系通过同源细胞群的平行扩增独立地进化出更高的认知能力。
The avian dorsal telencephalon has two vast territories, the nidopallium and the mesopallium, both of which have been shown to contribute substantially to higher cognitive functions. From their connections, these territories have been proposed as equivalent to mammalian neocortical layers 2 and 3, various neocortical association areas, or the amygdala, but whether these are analogies or homologies by descent is unknown. We investigated the molecular profiles of the mesopallium and the nidopallium with RNA-seq. Gene expression experiments established that the mesopallium, but not the nidopallium, shares a transcription factor network with the intratelencephalic class of neocortical neurons, which are found in neocortical layers 2, 3, 5, and 6. Experiments in alligators demonstrated that these neurons are also abundant in the crocodilian cortex and form a large mesopallium-like structure in the dorsal ventricular ridge. Together with previous work, these molecular findings indicate a homology by descent for neuronal cell types of the avian dorsal telencephalon with the major excitatory cell types of mammalian neocortical circuits: the layer 4 input neurons, the deep layer output neurons, and the multi-layer intratelencephalic association neurons. These data raise the interesting possibility that avian and primate lineages evolved higher cognitive abilities independently through parallel expansions of homologous cell populations.