Efficacy of calcium channel blockers as maintenance therapy for asthma.
Efficacy of calcium channel blockers as maintenance therapy for asthma.
复制标题
钙通道阻滞剂作为哮喘维持治疗的功效。
DOI：
10.1046/j.0306-5251.2001.01560.x
复制
发表时间：
2002
影响因子：
3.4
通讯作者：
Hendeles,Leslie
中科院分区：
文献类型：
--
作者：
AnnTwiss,Mary;Harman,Eloise;Chesrown,Sarah;Hendeles,Leslie
AimsPrevious bronchoprovocation studies indicate that nifedipine attenuates airway responsiveness to several stimuli whereas diltiazem has no effect. The aim of this study was to determine whether such studies predict the efficacy of calcium channel blockers as maintenance therapy for persistent asthma.MethodsTwenty‐one otherwise healthy adults with persistent asthma, mean age 25 years, completed treatment with maximum tolerated doses of placebo (P), nifedipine (N), and diltiazem (D) in a double‐blind, randomized, three‐treatment, three‐period, crossover manner, each for 4 weeks. Frequency and severity of asthmatic symptoms were recorded twice daily, as well as peak expiratory flow and frequency of ‘prn’ use of inhaled terbutaline. Blood pressure, heart rate, P‐R interval of the ECG and spirometry were measured biweekly. At the end of each treatment, airway responsiveness to exercise was measured.ResultsThe mean (s.e. mean)% of days with wheeze was 69±7% during P, 75±6% during N and 72±6% during D (P=0.7). FEV1was 79±2% of predicted during P, 81±2% during N and 79±2% during D (P=0.6). The decrease in FEV1after exercise was 32±4% during P, 32±5% during N and 27±4% during D (P=0.5). Heart rate was elevated during N (P=0.0002) whereas P‐R interval was prolonged during D (P=0.0001).ConclusionsMaintenance therapy with calcium channel blockers, at doses that produce cardiovascular effects, do not suppress the signs and symptoms of persistent asthma. Previous bronchoprovocation studies did not predict these results.
