Birth asphyxia measured by the pH value of the umbilical cord blood may predict an increased risk of attention deficit hyperactivity disorder
Birth asphyxia measured by the pH value of the umbilical cord blood may predict an increased risk of attention deficit hyperactivity disorder
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DOI：
10.1111/apa.13807
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发表时间：
2017-06-01
期刊：
影响因子：
3.8
通讯作者：
Arah, Onyebuchi
中科院分区：
文献类型：
--
作者：
Mikkelsen, Susanne Hvolgaard;Olsen, Jorn;Arah, Onyebuchi
目的：虽然出生窒息是新生儿和儿童发病率和死亡率的主要危险因素，但尚未对其与注意缺陷多动障碍（ADHD）的关系进行过多研究。我们研究了是否出生窒息测量的pH值的血液中的脐动脉cord与儿童ADHD.Method：一个基于人口的队列295 687名儿童出生在芬兰1991年和2002年之间，直到2007年12月31日。ADHD被国际疾病分类第10版确定为多动障碍的诊断。我们研究了ADHD的风险与不同的pH值使用考克斯回归，考虑到时间trends into consideration.Results：当与参考组相比，pH值低于7.10显着相关的ADHD的风险增加。最大的风险是在pH值
Aim: Although birth asphyxia is a major risk factor for neonatal and childhood morbidity and mortality, it has not been investigated much in relation to attention deficit hyperactivity disorder (ADHD). We examined whether birth asphyxia measured by the pH of the blood in the umbilical artery cord was associated with childhood ADHD.Method: A population-based cohort of 295 687 children born in Finland between 1991 and 2002 was followed until December 31, 2007. ADHD was identified by the International Classification of Diseases, 10th edition, as a diagnosis of hyperkinetic disorder. We examined the risk of ADHD with varying pH values using Cox regression, taking time trends into consideration.Results: When compared to the reference group, a pH value below 7.10 was significantly associated with an increased risk of ADHD. The strongest risks were observed among children with a pH value