Cellular changes and apoptosis in the spleens and peripheral blood of mice infected with blood-stage Plasmodium chabaudi chabaudi AS
Cellular changes and apoptosis in the spleens and peripheral blood of mice infected with blood-stage Plasmodium chabaudi chabaudi AS
复制标题
DOI：
10.1128/iai.68.3.1485-1490.2000
复制
发表时间：
2000-03-01
影响因子：
3.1
通讯作者：
Troye-Blomberg, M
中科院分区：
文献类型：
--
作者：
Helmby, H;Jönsson, G;Troye-Blomberg, M
感染血液阶段的查鲍迪疟原虫会导致脾肿大、外周血白细胞增多和免疫系统的主要激活。比较了沙包氏疟原虫感染BALB/c小鼠脾和外周血中T细胞、B细胞和巨噬细胞的频率和绝对数量，发现在急性感染过程中T细胞、B细胞和巨噬细胞的数量发生了显著变化。不同类型细胞在脾和外周血中的再分布动力学不同，T细胞和B细胞在血液中的出现频率和绝对数在脾中较低。在沙包虫急性感染过程中，小鼠脾细胞的凋亡率和绝对细胞数均增加，T细胞、B细胞和巨噬细胞均参与其中。Fas和Fas配体在脾组织中的表达均增强。综上所述，我们的数据提供了关于在小鼠模型的血液期疟疾感染期间免疫系统中发生的复杂细胞相互作用的新信息。
Infection with blood-stage Plasmodium chabaudi chabaudi AS results in splenomegaly, peripheral leukocytosis, and a major activation of the immune system. The frequencies and absolute numbers of T-cell, B-cell, and macrophage populations in spleen and peripheral blood from P. chabaudi-infected BALB/c mice were compared and found to be significantly altered during acute infection. The kinetics of the redistribution of the different cell types in spleen and peripheral blood were different, with T and B cells appearing in the blood when their frequencies and absolute numbers in the spleen were low. The frequency and absolute number of apoptotic cells in the spleen were increased during acute P. chabaudi infection and involved both T cells, B cells, and macrophages. Both Fas and Fas-ligand expression were increased in the spleen. Taken together, our data provide new information on the complex cellular interactions that take place in the immune system during blood-stage malaria infection in a mouse model.