Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products.
Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products.
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DOI：
10.21037/atm.2019.04.25
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发表时间：
2019-04
影响因子：
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通讯作者：
P. A. Wellham;Dong-Hyun Kim;M. Brock;C. D. de Moor
中科院分区：
文献类型：
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作者：
P. A. Wellham;Dong-Hyun Kim;M. Brock;C. D. de Moor
虫草素，或3 '-脱氧腺苷，是由昆虫病原真菌蛹虫草产生的代谢产物，并作为癌症和炎症条件的潜在先导化合物正在进行深入研究。虫草素最初是由Cunningham等人（1）从一种虫草菌的培养滤液中提取的。militaris培养物，其由分生孢子生长。随后，虫草素也被报道由Ophiocorphiumsinensis产生（2），这是一种历史上被用作传统药物和健康食品的物种，主要在中国和远东地区（3）。栽培黄瓜军事行动现在被广泛用作较便宜的替代品。此外，这些真菌也在全球范围内获得了天然食品补充剂的市场，在英国和美国有30-50种产品声称含有虫草。
Cordycepin, or 3'-deoxyadenosine, is a metabolite produced by the insect-pathogenic fungus Cordyceps militaris and is under intense investigation as a potential lead compound for cancer and inflammatory conditions. Cordycepin was originally extracted by Cunningham et al. (1) from a culture filtrate of a C. militaris culture that was grown from conidia. Subsequently, cordycepin has also been reported to be produced by Ophiocordyceps sinensis (2), a species historically used as a traditional medicine and health food, primarily in China and the wider Far East (3). Cultivated C. militaris is now widely in use as less expensive substitute. In addition, these fungi are also globally gaining a market as natural food supplements, with 30–50 products claiming to contain Cordyceps available in the UK and the USA.