Risk of malignancy in focal thyroid lesions identified by 18F-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography: evidence from a large series of studies
Risk of malignancy in focal thyroid lesions identified by 18F-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography: evidence from a large series of studies
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DOI：
10.1007/s13277-014-1813-4
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发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Ji, Qing-hai
中科院分区：
文献类型：
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作者：
Qu, Ning;Zhang, Ling;Ji, Qing-hai
在F-18-FDG正电子发射断层扫描或正电子发射断层扫描/计算机断层扫描（F-18-FDG PET或PET/CT）上发现的局灶性甲状腺偶发瘤提示甲状腺恶性肿瘤的高风险。对最大标准化摄取值（SUVmax）能否区分局灶性病变中的良恶性组织进行Meta分析，并探讨SUVmax诊断恶性肿瘤的临界值。本次荟萃分析共纳入29项研究。结果表明，当通过超声测量时，两个良性和恶性组的大小没有统计学显著差异（95%置信区间（CI），-0.79至0.03 min; p = 0.07），而在恶性组中观察到显著更高的局灶性SUVmax（95% CI，0.34至1.05; p = 0.0001）。总之，该荟萃分析的结果表明，较高的局灶性F-18-FDG SUVmax与甲状腺恶性肿瘤的较高风险相关，尤其是在阈值为3.3或更高时。
Focal thyroid incidentaloma identified on F-18-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (F-18-FDG PET or PET/CT) indicates a high risk of thyroid malignancy. A meta-analysis was performed to investigate whether the maximum standardized uptake value (SUVmax) could discriminate between benign and malignant tissues in focal lesions and to explore the cutoff value of SUVmax for the diagnosis of malignancy. A total of 29 studies were involved in this meta-analysis. The results indicated that there was no statistically significant difference in the size of the two benign and malignant groups when measured by ultrasonography (95 % confidence interval (CI), -0.79 to 0.03 min; p = 0.07), while a significantly higher focal SUVmax was observed in the malignant group (95 % CI, 0.34 to 1.05; p = 0.0001). In conclusion, the findings of this meta-analysis suggest that a higher focal F-18-FDG SUVmax was associated with a higher risk of thyroid malignancy, especially at a threshold of 3.3 or more.