Twenty-four-hour Cortisol Profiles Demonstrate Exaggerated Nocturnal Rise in Diabetic Children
Twenty-four-hour Cortisol Profiles Demonstrate Exaggerated Nocturnal Rise in Diabetic Children
复制标题
二十四小时皮质醇曲线显示糖尿病儿童夜间皮质醇升高过度
作者：
T. Lebinger;Paul V. Saenger;D. Fukushima;J. Kream;R. Wu;J. Finkelstein
在12名正常儿童和8名胰岛素依赖型非酮症糖尿病儿童中，每天注射一次胰岛素，每20分钟测定一次血浆皮质醇，持续24小时。糖尿病患儿每20 min测一次血糖。皮质醇分泌的昼夜模式是相同的。两组的平均24小时血浆皮质醇相似，但糖尿病儿童在0200和0920小时之间显著升高。糖尿病儿童皮质醇峰值水平高于正常儿童。在糖尿病受试者中，平均血糖和平均血浆皮质醇之间或夜间血糖变化和平均夜间血浆皮质醇之间没有发现相关性。这些研究表明糖尿病儿童血浆皮质醇的正常夜间升高与血糖水平无关。
Plasma cortisol was measured every 20 min for 24 h in 12 normal and 8 insulin-dependent, nonketotic, diabetic children treated with one daily injection of insulin. Plasma glucose was also measured every 20 min in the diabetic children. The diurnal pattern of cortisol secretion was identical. The mean 24- h plasma cortisol was similar in both groups, but significantly elevated in the diabetic children between 0200 and 0920 h. Peak cortisol levels were higher in the diabetic than in the normal children. No correlation was found between average plasma glucose and average plasma cortisol, or between the nocturnal change in plasma glucose and average nocturnal plasma cortisol in the diabetic subjects. These studies demonstrate an exaggeration of the normal nocturnal rise in plasma cortisol in diabetic children not related to the levels of plasma glucose.
利用连续皮下胰岛素输注短期改善血糖控制：对胰岛素依赖型糖尿病中反调节激素和血脂的 24 小时综合浓度的影响。
DOI：
10.1210/jcem-54-3-504
发表时间：
1982
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hershcopf,R;Plotnick,LP;Kaya,K;Benedict,GW;Hadji-Georgopoulos,A;Margolis,S;Kowarski,AA
通讯作者：
Kowarski,AA