High prevalence of TT virus (TTV) infection in patients on maintenance hemodialysis: Frequent mixed infections with different genotypes and lack of evidence of associated liver disease
High prevalence of TT virus (TTV) infection in patients on maintenance hemodialysis: Frequent mixed infections with different genotypes and lack of evidence of associated liver disease
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DOI：
10.1002/(sici)1096-9071(199911)59:3
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发表时间：
1999-11-01
影响因子：
12.7
通讯作者：
Bukh, J
中科院分区：
文献类型：
--
作者：
Forns, X;Hegerich, P;Bukh, J
最近，一种新的DNA病毒，TT病毒（TTV），被确定在输血后非甲-庚型肝炎患者。我们分析了96例西班牙长期血液透析患者TTV感染的患病率和临床意义。巢式PCR检测TTV DNA的51例（53%），显着高于健康献血员的患病率。单纯TTV感染者2例（7.7%）出现持续性肝功能异常，而丙型肝炎、B型肝炎或两者同时感染者16例（75%）出现持续性肝功能异常（P < 0.01）。血液透析患者中常见多种TTV毒株混合感染，包括不同的主要基因型。与明显感染单一TTV毒株的患者（8.9 +/- 11）相比，这些患者接受了显著更多的血液单位（22.7 +/- 20）（P = 0.01）。系统发育分析TTV从感染的患者确定株的基因型1，2，3和4。总之，TTV感染在血液透析患者中很常见，但与肝脏疾病无关。(C)1999 Wiley-Liss，Inc.
Recently, a novel DNA virus, TT virus (TTV), was identified in patients with post-transfusion non-A-G hepatitis. We analyzed the prevalence and clinical implications of TTV infection in a cohort of 96 Spanish patients on long-term hemodialysis. TTV DNA was detected by nested PCR in 51 (53%) of 96 patients, a prevalence significantly higher than that found in healthy blood donors. Persistent liver test abnormalities were found in only 2 (7.7%) of 26 patients infected with TTV alone, compared with 12 (75%) of 16 patients infected with hepatitis C or hepatitis B virus, or both (P < 0.01). Mixed infections with multiple strains of TTV, including different major genotypes, were common in patients on hemodialysis. These patients had received a significantly greater number of blood units (22.7 +/- 20) compared with patients apparently infected with a single strain of TTV (8.9 +/- 11) (P = 0.01). Phylogenetic analyses of TTV from infected patients identified strains of genotypes 1, 2, 3, and 4. In summary, TTV infection was common in patients on hemodialysis but was not associated with liver disease. (C) 1999 Wiley-Liss, Inc.