EFFECT OF LIVE AND HEAT-KILLED BACTERIA ON THE SECRETORY ACTIVITY OF PANETH CELLS IN GERM-FREE MICE
EFFECT OF LIVE AND HEAT-KILLED BACTERIA ON THE SECRETORY ACTIVITY OF PANETH CELLS IN GERM-FREE MICE
复制标题
DOI：
10.1007/bf00215451
复制
发表时间：
1988-01-01
影响因子：
3.6
通讯作者：
SATOH, Y
中科院分区：
文献类型：
--
作者：
SATOH, Y
无菌小鼠给予活的或热杀死的兼性厌氧菌，回肠潘氏细胞的超微结构进行了定量研究，特别是分泌颗粒显示一个二分的子结构（中央核心和周边晕）。施用活的或热灭活的细菌后，潘氏细胞中分泌颗粒的核心所占据的面积减少，并且在隐窝腔中观察到胞吐的核心物质。分泌颗粒晕所占面积无变化。所检查的潘氏细胞均未吞噬细菌。结论：某些细菌可能会影响潘氏细胞分泌颗粒中所含抗菌剂的分泌。
Germ-free mice were given live or heat-killed facultative anaerobes, and the ultrastructure of ileal Paneth cells was quantitatively examined with special reference to secretory granules showing a bipartite substructure (central core and peripheral halo). After administering live or heatkilled bacteria, there was a decrease in the area occupied by the cores of secretory granules in Paneth cells, and exocytosed core material was observed in the crypt lumen. There were no changes in the area occupied by the halo of secretory granules. None of the examined Paneth cells phagocytosed bacteria. It is concluded that certain bacteria may affect the secretion of antibacterial agents contained in the secretory granules of Paneth cells.