Intravenous triglycerides fail to elicit satiety in sham-feeding rats.
Intravenous triglycerides fail to elicit satiety in sham-feeding rats.
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静脉注射甘油三酯不能引起假喂养大鼠的饱腹感。
DOI：
10.1152/ajpregu.1993.264.2.r409
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Gibbs,J
中科院分区：
文献类型：
--
作者：
Greenberg,D;Smith,GP;Gibbs,J
本文观察了静脉输注脂肪对大鼠的饱腹感。假喂养时，下腔静脉或肝门静脉注入2.5~10.0千卡的脂肪。在60分钟的测试中，通过任何一种途径静脉注射Intralipid对假喂养没有影响。在早期的工作中，我们发现十二指肠注入Intralipid迅速抑制假喂食，并在与本研究相同的测试条件下引发典型的饱腹感行为。静脉输注Intralipid对假喂养的影响缺乏进一步的证据，证明Intralipid的饱腹感作用存在预吸收部位。
The satiating effect of intravenous fat infusions was investigated in sham-feeding rats. Intralipid infusions at loads of 2.5-10.0 kcal were administered into either the inferior vena cava or the hepatic-portal vein during sham feeding. Intravenous infusions of Intralipid by either route had no effect on sham feeding during 60-min tests. In earlier work we found that duodenal infusions of Intralipid rapidly inhibited sham feeding and elicited behaviours typical of satiety under test conditions identical to those of the present study. The lack of effect of intravenous infusions of Intralipid on sham feeding is further evidence for a preabsorptive site of action for the satiety effect of Intralipid.