Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography
Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography
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DOI：
10.1002/lapl.201110014
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发表时间：
2011-06-01
影响因子：
1.7
通讯作者：
Lademann, J.
中科院分区：
文献类型：
--
作者：
Koenig, K.;Breunig, H. G.;Lademann, J.
早期诊断的最终挑战是无标记的高分辨率组织内成像，而无需进行物理活检。一种新型的混合飞秒激光断层扫描仪提供了在体内的光学活检的基础上的非线性激发的自体荧光和检测的脂质和水的汽车的人皮肤。应用包括皮肤癌检测、皮内纳米颗粒的生物安全性测试以及抗衰老产品的测试。
The ultimate challenge for early diagnostics is label-free high-resolution intratissue imaging without taking physical biopsies. A novel hybrid femtosecond laser tomograph provides in vivo optical biopsies of human skin based on non-linear excitation of autofluorescence and the detection of lipids and water by CARS. Applications include skin cancer detection, biosafety tests of intradermal nanoparticles, and the testing of anti-aging products.