Design and implementation of a wireless capsule suitable for autofluorescence intensity detection in biological tissues.
Design and implementation of a wireless capsule suitable for autofluorescence intensity detection in biological tissues.
复制标题
设计和实现适合生物组织中自发荧光强度检测的无线胶囊。
DOI：
10.1109/tbme.2012.2222641
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Al-Rawhani MA
中科院分区：
文献类型：
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作者：
Al-Rawhani MA
我们报道了一种能够检测哺乳动物肠道组织中的自体荧光(AF)的微型系统的设计、制造、测试和封装。该系统包括专用集成电路(ASIC)、发光二极管、滤光器、控制单元和无线电发射机。ASIC包含一个高压电荷泵和单光子雪崩二极管探测器(SPAD)。电荷泵将SPAD偏置在击穿电压之上，以工作在盖革模式。SPAD在520 nm处的光子探测效率为37%，与人体肠道主要荧光团黄素腺嘌呤二核苷酸的AF发射峰相对应。该ASIC采用商用三势垒高压CMOS线工艺制造。整个器件的工作电压为3 V，平均电流为7.1 mA，使用两块165毫安SR44电池可连续工作长达23小时。
We report on the design, fabrication, testing, and packaging of a miniaturized system capable of detecting autofluorescence (AF) from mammalian intestinal tissue. The system comprises an application-specific integrated circuit (ASIC), light-emitting diode, optical filters, control unit, and radio transmitter. The ASIC contains a high-voltage charge pump and single-photon avalanche diode detector (SPAD). The charge pump biases the SPAD above its breakdown voltage to operate in Geiger mode. The SPAD offers a photon detection efficiency of 37% at 520 nm, which corresponds to the AF emission peak of the principle human intestinal fluorophore, flavin adenine dinucleotide. The ASIC was fabricated using a commercial triple-well high-voltage CMOS process. The complete device operates at 3 V and draws an average of 7.1 mA, enabling up to 23 h of continuous operation from two 165-mAh SR44 batteries.