Angiotensinogen Gene M235T and T174M Polymorphisms and Susceptibility of Pre-Eclampsia: A Meta-Analysis
Angiotensinogen Gene M235T and T174M Polymorphisms and Susceptibility of Pre-Eclampsia: A Meta-Analysis
复制标题
血管紧张素原基因 M235T 和 T174M 多态性与先兆子痫的易感性：荟萃分析
DOI：
10.1111/j.1469-1809.2012.00722.x
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发表时间：
2012-09-01
影响因子：
1.9
通讯作者：
Li, Dongna
中科院分区：
文献类型：
--
作者：
Lin, Rong;Lei, Yunping;Li, Dongna
关于血管紧张素原（AGT）基因多态性与先兆子痫（PE）发生风险的关系，目前的报道存在争议。我们进行了一项荟萃分析，以检查AGT多态性与PE风险之间的关联：M235T（31项研究，涉及2555例患者和6114例对照）和T174M（6项研究，涉及681例患者和2076例对照）。对于M235T多态性，与MM基因型相比，TT基因型增加了PE的风险（比值比1.61，95%置信区间1.222.14，P= 0.001）。当按种族分层时，TT基因型在高加索人和蒙古人中与较高的PE风险显著相关，但在非洲人中则不相关。在M235T多态性的所有三种遗传模型下也获得了类似的结果。对于T174M多态性，在比较中（MT与TT和MM与TT）和任何遗传模型下均未发现显著关联。排除高度显着的违反HardyWeinberg平衡的研究和敏感性分析的分析进一步加强了这些协会的有效性。本研究未观察到发表偏倚。这项荟萃分析表明，AGT M235 T多态性与PE显著相关，而T174 M多态性则不相关。
There are controversies in reports on the association of the angiotensinogen (AGT) gene polymorphisms with the risk of developing pre-eclampsia (PE). We performed a meta-analysis to examine the association between the AGT polymorphisms and PE risk: M235T (31 studies involving 2555 patients and 6114 controls) and T174M (six studies involving 681 patients and 2076 controls). For the M235T polymorphism, the TT genotype increased the PE risk as compared to the MM genotype (odds ratio 1.61, 95% confidence intervals 1.222.14, P= 0.001). When stratified by ethnicity, the TT genotype remained significantly associated with higher PE risk in Caucasians and Mongolians but not in Africans. Similar results were also obtained under all three genetic models of the M235T polymorphism. For the T174M polymorphism, no significant association was found in the comparisons (MT vs. TT and MM vs. TT) and under any genetic models. The analysis excluding the highly significant HardyWeinberg equilibrium-violating studies and sensitivity analysis further strengthened the validity of these associations. No publication bias was observed in this study. This meta-analysis demonstrates that the AGT M235T polymorphism is significantly associated with PE whereas the T174M polymorphism is not.