Fluorescence bronchoscopy for localization of carcinoma in situ.
Fluorescence bronchoscopy for localization of carcinoma in situ.
复制标题
荧光支气管镜检查用于原位癌定位。
DOI：
10.1118/1.595374
复制
发表时间：
1983
期刊：
影响因子：
3.8
通讯作者：
Huth,GC
中科院分区：
文献类型：
--
作者：
Profio,AE;Doiron,DR;Balchum,OJ;Huth,GC
已经开发了一种荧光支气管镜系统，用于通过先前注射的肿瘤特异性试剂血卟啉衍生物的荧光对肺肿瘤进行成像。癌灶已经定位，但有太多的假阳性和假阴性。已经实施了一种新的系统，其允许在荧光观察和在白色光照明下观察与常规支气管镜检查相同的区域之间快速切换。激发源是耦合到熔融石英光纤光导体的紫色氪离子激光器，具有发散微透镜以均匀地传播光。第三代微通道板图像增强器放大微弱的荧光，用于观察和视频显示、记录和分析。一个可移动的镜子和潜望镜绕过增强器进行正常的彩色观察和视频显示和记录，激光快门关闭，白色光快门打开。这有助于准确定位、比较彩色和荧光图像以及活检期间的精确采样。改进后的系统应能减少因活检取样误差而导致的假阳性率，并与视频分析仪一起减少不确定结果。
A fluorescence bronchoscope system has been developed for imaging lung tumors by fluorescence of a previously injected, tumor‐specific agent hematoporphyrin derivative. Carcinomain situhas been localized, but there are too many false positives and negatives. A new system has been implemented which allows rapid switching between viewing of fluorescence, and viewing of the same area under white light illumination as in conventional bronchoscopy. The excitation source is a violet krypton ion laser coupled to a fused quartz fiber light conductor, with a diverging microlens to spread the light uniformly. A third‐generation, microchannel plate image intensifier amplifies the weak fluorescence for viewing and video display, recording, and analysis. A movable mirror and periscope bypasses the intensifier for normal color viewing and video display and recording, with the laser shutter closed and the white light shutter open. This facilitates accurate localization, comparison of the color and fluorescence images, and precise sampling during biopsy. The improved system should reduce the false positive rate due to biopsy sampling error, and together with the video analyzer should reduce indeterminate results.