Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical studies, pulmonary function studies, and bronchoalveolar lavage.
Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical studies, pulmonary function studies, and bronchoalveolar lavage.
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镓 67 扫描对结节病肺泡炎进行分期：与临床研究、肺功能研究和支气管肺泡灌洗的相关性。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
R. Crystal
中科院分区：
文献类型：
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作者：
B. Line;G. Hunninghake;B. Keogh;A. Jones;Johnston Gs;R. Crystal
目前关于结节病发病机制的概念表明，这种疾病的肺泡炎与肺内单核吞噬细胞和活化 T 淋巴细胞数量的增加有关。为了确定 67Ga 扫描（一种常用于评估炎症的方法）是否有助于对结节病肺泡炎进行分期，我们研究了 41 名患有这种疾病的患者，并将肺部 67Ga 积累的估计值与这些患者的临床、X 线摄影、生理和支气管肺泡灌洗研究相关联。尽管与对照受试者相比，65% 的结节病患者肺部 67Ga 积聚量增加，但镓摄取程度与临床、X 射线照相或生理数据之间仅发现微弱相关性（所有比较，r 小于 +/- 0.42）。相反，67Ga 的摄取与通过支气管肺泡灌洗从这些患者的肺部回收的淋巴细胞和 T 淋巴细胞的数量存在很强的相关性（p 小于 0.0001，r 大于或等于 0.67，两种比较）。该数据表明，镓的摄取反映了结节病中 T 淋巴细胞介导的肺泡炎成分的强度。由于 67Ga 扫描是非侵入性的、操作简单且广泛使用，因此它们应该被证明有助于分期结节病的活动并做出针对该疾病的肺泡炎的治疗决策。
Current concepts of the pathogenesis of sarcoidosis suggest that the alveolitis of this disorder is related to increased numbers of mononuclear phagocytes and activated T-lymphocytes within the lung. To determine if 67Ga scanning, a procedure commonly used in the evaluation of inflammation, would be useful in staging the alveolitis of sarcoidosis, we studied 41 patients with this disorder and correlated estimates of pulmonary 67Ga accumulation with clinical, roentgenographic, physiologic, and bronchoalveolar lavage studies in these patients. Although 65% of patients with sarcoidosis showed increased amounts of 67Ga accumulation in the lung compared with control subjects, only weak correlations (r less than +/- 0.42, all comparisons) were found between the degree of gallium uptake and the clinical, roentgenographic, or physiologic data. In contrast, there was a strong correlation of 67Ga uptake and the number of lymphocytes and T-lymphocytes recovered from the lungs of these patients by bronchoalveolar lavage (p less than 0.0001, r greater than or equal to 0.67, both comparisons). This data suggested that gallium uptake reflects the intensity of the T-lymphocytes mediated component of the alveolitis in sarcoidosis. Because 67Ga scans are noninvasive, simple to perform, and widely available, they should prove useful to stage the activity of sarcoidosis and to make decisions regarding therapy directed against the alveolitis of the disease.