Olfactory signals mediate social buffering of conditioned fear responses in male rats
Olfactory signals mediate social buffering of conditioned fear responses in male rats
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DOI：
10.1016/j.bbr.2012.11.017
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发表时间：
2013-03
影响因子：
2.7
通讯作者：
Yuji K. Takahashi;Y. Kiyokawa;Y. Kodama;Sayaka Arata;Y. Takeuchi;Y. Mori
中科院分区：
文献类型：
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作者：
Yuji K. Takahashi;Y. Kiyokawa;Y. Kodama;Sayaka Arata;Y. Takeuchi;Y. Mori
在群居动物中，亲和同种的存在会加剧急性应激反应，这被称为社会缓冲。我们以前曾报道，社会缓冲减轻了恐惧反应的雄性大鼠听觉条件刺激，已配对足冲击。随后的研究表明，由主要嗅觉上皮细胞感知的信号对社会缓冲很重要。由于嗅觉信号是由主要的嗅觉上皮细胞感知的信号，我们假设，我们可以诱导条件性恐惧反应的社会缓冲，提出来自同种的嗅觉信号。为了验证这一假设，我们将恐惧条件受试者暴露于条件刺激，无论是在一个干净的测试盒中，还是在一个预先通过保持同种作为气味供体而加臭的测试盒中。当受试者在干净的测试盒中进行测试时，他们表现出行为恐惧反应，并增强了室旁核的Fos表达。相反，同种嗅觉信号的存在下，这些恐惧反应和Fos的表达。这些结果表明，嗅觉信号抑制条件性恐惧反应。Fos在嗅脚和杏仁核后内侧区域的表达表明，这种抑制涉及与社会缓冲相同的神经机制。综上所述，我们得出结论，嗅觉信号介导的条件性恐惧反应的社会缓冲。
In social animals, the presence of an affiliative conspecific alleviates acute stress responses, and this is called social buffering. We previously reported that social buffering mitigates the fear responses of male rats to auditory conditioned stimuli that had been paired with foot shocks. Subsequent studies revealed that signals that are perceived by the main olfactory epithelium are important for social buffering. Because olfactory signals are the signal perceived by the main olfactory epithelium, we hypothesized that we could induce the social buffering of conditioned fear responses by presenting olfactory signals that were derived from a conspecific. In order to test this hypothesis, we exposed fear-conditioned subjects to a conditioned stimulus either in a clean test box or in a test box that was odorized by keeping a conspecific in it as an odor donor beforehand. When the subjects were tested in the clean test box, they showed behavioral fear responses and enhanced Fos expression in the paraventricular nucleus. In contrast, the presence of conspecific olfactory signals blocked these fear responses and Fos expression. These results suggested that olfactory signals suppress conditioned fear responses. Fos expression in the posteromedial region of the olfactory peduncle and amygdala suggested that this suppression involves the same neural mechanisms as those of social buffering. Taken together, we concluded that olfactory signals mediate the social buffering of conditioned fear responses.