Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex.
Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex.
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DOI：
10.1038/nn.3918
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发表时间：
2015-02
影响因子：
25
通讯作者：
Lee D
中科院分区：
文献类型：
--
作者：
Donahue CH;Lee D
背外侧前额叶皮层（DLPFC）的神经元编码各种各样的感觉和记忆信号，但很少有人知道这些信息是如何在决策过程中动态路由的。我们分析了猴子执行概率反转任务的DLPFC中的神经元活动，其中关于奖励的概率和大小的信息分别由目标颜色和数字线索提供。给定颜色的目标位置在试验中是随机的，因此与随后的选择无关。DLPFC神经元编码与任务相关和不相关的功能，任务相关的记忆信号编码一致的选择信号。此外，只有与先前事件相关的任务相关信号在奖励结果之后被更鲁棒地编码。因此，多种类型的神经信号在DLPFC中被灵活地路由，以便有利于使奖励最大化的动作。
Neurons in the dorsolateral prefrontal cortex (DLPFC) encode a diverse array of sensory and mnemonic signals, but little is known about how this information is dynamically routed during decision making. We analyzed the neuronal activity in the DLPFC of monkeys performing a probabilistic reversal task where information about the probability and magnitude of reward was provided by the target color and numerical cues, respectively. The location of the target of a given color was randomized across trials, and therefore was not relevant for subsequent choices. DLPFC neurons encoded signals related to both task-relevant and irrelevant features, and task-relevant mnemonic signals were encoded congruently with choice signals. Furthermore, only the task-relevant signals related to previous events were more robustly encoded following rewarded outcomes. Thus, multiple types of neural signals are flexibly routed in the DLPFC so as to favor actions that maximize reward.