Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
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Indimicins A-E，来自深海衍生链霉菌属的双吲哚生物碱。
DOI：
10.1021/np500362p
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发表时间：
2014-08-01
影响因子：
5.1
通讯作者：
Zhang, Changsheng
中科院分区：
文献类型：
--
作者：
Zhang, Wenjun;Ma, Liang;Zhang, Changsheng
从海洋来源的链霉菌中分离得到5个新的双吲哚生物碱，其中1‘，3’-二甲基-2‘-氢吲哚部分为吲哚类化合物。03032，以及两个新化合物--莱那霉素F和G(6和7)。通过对它们的MS和核磁共振波谱数据的详细解释，确定了它们的平面结构，并通过X-射线晶体分析(1)、CD光谱比较(2-4)和量子化学计算(5)确定了它们的绝对构型。青霉素B(2)对MCF-7细胞具有中等的细胞毒活性。
Five new bisindole alkaloids, indimicins A-E (1-5), bearing a unique 1',3'-dimethyl-2'-hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 2-4), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.