Plasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patients
Plasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patients
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DOI：
10.1111/1756-185x.12115
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Ohira, Hiromasa
中科院分区：
文献类型：
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作者：
Iwadate, Haruyo;Kobayashi, Hiroko;Ohira, Hiromasa
目的探讨骨桥蛋白（OPN）与类风湿关节炎（RA）骨吸收指标及治疗效果的关系。通过疾病活动性评分（DAS）28、红细胞沉降率（ESR）、C反应蛋白（CRP）、类风湿因子（RF）和基质金属蛋白酶（MMP）-3水平评估RA疾病活动性。酶联免疫吸附试验（ELISA）测定血浆和尿液中OPN水平。采用ELISA法检测血清抗酒石酸酸性磷酸酶（TRACP）5 b和尿1型胶原（CTX）-1 C端肽的水平。结果血浆全长OPN水平（P-fOPN）与TRACP 5 b水平显著相关（r= 0. 44，P
AimTo assess whether any form of osteopontin (OPN) is correlated with bone resorption markers or treatment effects in rheumatoid arthritis (RA).MethodSubjects comprised 119 patients with RA. RA disease activity was evaluated by Disease Activity Score (DAS) 28, erythrocyte sedimentation rate (ESR), and levels of C-reactive protein (CRP), rheumatoid factor (RF) and matrix metalloproteinase (MMP)-3. OPN levels in plasma and urine were measured by enzyme-linked immunosorbent assay (ELISA). Levels of tartrate-resistant acid phosphatase (TRACP) 5b in serum and C-terminal telopeptide of type 1 collagen (CTX)-1 in urine were measured by ELISA. Patients were divided into responder and nonresponder groups, and OPN levels were compared at baseline and after treatment.ResultsLevels of full-length OPN in plasma (P-fOPN) were significantly correlated with levels of TRACP 5b (r=0.44, P