Vascular disease among hospitalized multiple sclerosis patients
Vascular disease among hospitalized multiple sclerosis patients
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DOI：
10.1159/000128103
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Alderman, Michael H.
中科院分区：
文献类型：
--
作者：
Allen, Norrina B.;Lichtman, Judith H.;Alderman, Michael H.
背景：我们调查了患有和不患有多发性硬化症（MS）的住院患者心脑血管疾病的患病率。方法：本研究使用了纽约市从 1988 年到 2002 年超过 1500 万例住院患者的全州规划和研究合作系统数据集。我们确定了 40-84 岁的 MS 患者，他们因 MS 或相关并发症以外的原因住院。 MS 患者在年龄、性别、种族/民族和保险方面进行 1:2 匹配。结果包括缺血性心脏病的主要出院诊断[国际疾病分类，第九版修订版 (ICD-9) 410 - 414]、心肌梗死 (ICD-9 410) 和缺血性中风 (ICD-9 434, 436)。使用多变量逻辑回归来比较 MS 和非 MS 患者的血管疾病结果，并控制人口和临床因素。结果：我们的研究纳入了 9,949 例住院的多发性硬化症患者和 19,898 例住院的匹配的非多发性硬化症对照患者。与匹配的患者相比，多发性硬化症患者因缺血性心脏病（OR = 0.58，95% CI = 0.51 - 0.66）或心肌梗死（OR = 0.78，95% CI = 0.64 - 0.96）住院的可能性较小，但因缺血性中风住院的可能性更高（OR = 1.66，95% CI = 1.33 - 2.09）非 MS 对照。结论：与一般非 MS 人群相比，MS 患者因缺血性心脏病和心肌梗死住院的比例降低，但因缺血性卒中住院的比例升高。版权所有 (C) 2008 S. Karger AG，巴塞尔。
Background: We examined the prevalence of cardiac and cerebrovascular disease among hospitalized patients with and without multiple sclerosis (MS). Methods: This study used the Statewide Planning and Research Cooperate System data set of over 15 million hospitalizations in New York City from 1988 through 2002. We identified MS patients 40 84 years of age who were hospitalized for reasons other than MS or related complications. MS patients were matched 1: 2 on age, gender, race/ethnicity, and insurance. Outcomes included a principal discharge diagnosis of ischemic heart disease [International Classification of Diseases, Ninth Revision (ICD-9) 410 - 414], myocardial infarction (ICD-9 410), and ischemic stroke (ICD-9 434, 436). Multivariate logistic regression was used to compare vascular disease outcomes in MS and non-MS patients controlling for demographic and clinical factors. Results: Our study included 9,949 hospitalizations among MS patients and 19,898 hospitalizations for matched non-MS controls. MS patients were less likely to be hospitalized for ischemic heart disease (OR = 0.58, 95% CI = 0.51 - 0.66) or myocardial infarction (OR = 0.78, 95% CI = 0.64 - 0.96), but more likely to be hospitalized for ischemic stroke (OR = 1.66, 95% CI = 1.33 - 2.09) than matched non-MS controls. Conclusion: MS patients have decreased rates of hospital admission for ischemic heart disease and myocardial infarction, but increased rates of hospitalization for ischemic stroke as compared to the general non-MS population. Copyright (C) 2008 S. Karger AG, Basel.