Discrimination, adjusted correlation, and equivalence of imprecise tests: application to glucose tolerance
Discrimination, adjusted correlation, and equivalence of imprecise tests: application to glucose tolerance
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DOI：
10.1152/ajpendo.1999.276.2.e365
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发表时间：
1999-02-01
影响因子：
5.1
通讯作者：
Turner, R
中科院分区：
文献类型：
--
作者：
Levy, J;Morris, R;Turner, R
生理测试之间的比较研究通常不能令人满意地评估他们区分受试者的能力。我们推荐一个简单但全面的协议，使用重复测试，使用 I) 基础组间和组内 SD 之间的判别比 (DR)，2) 因测试不精确而导致的衰减调整相关系数，以及 3) 测试结果之间潜在线性关系的无偏估计来比较测试。比较了以下五种评估葡萄糖耐量的替代方法： 空腹血糖 (FPG) 作为单个样本或作为三个 5 分钟样本的平均值 (FPG(3))；低剂量静脉葡萄糖输注 (CIG) 期间的 1 小时和 2 小时血糖；以及 75 克口服葡萄糖耐量试验 (OGTT) 的 2 小时血浆葡萄糖。所有测试都有相似的 DR，范围为 2.6 到 4.2。 FPG和CIG测试之间调整后的相关性接近统一，OGTT和其他测试之间的相关性接近0.9，表明FPG3提供了与OGTT相似的信息。发现 FPG 浓度 6.0 和 7.1 相当于 1985 年世界卫生组织 OGTT 糖耐量受损和糖尿病的阈值（7.8 和 11.1 mmol/l）。
Comparison studies between physiological tests are often unsatisfactory for assessing their ability to distinguish between subjects. We recommend a simple but comprehensive protocol, using duplicate testing, that compares tests using I)the discriminant ratio (DR) between the underlying between- and within-subject SDs, 2) correlation coefficients adjusted for attenuation due to test imprecision, and 3) unbiased estimation of the underlying linear relationship between test results. The following five alternative methods for assessing glucose tolerance were compared: fasting plasma glucose (FPG) as a single sample or as the mean of three 5-min samples (FPG(3)); the 1- and 2-h glucose during a low-dose intravenous glucose infusion (CIG); and the 2-h plasma glucose from a 75-g oral glucose tolerance test (OGTT). All tests had similar DRs ranging from 2.6 to 4.2. The adjusted correlation between FPG and CIG tests approached unity, and those between OGTT and other tests were similar to 0.9, showing that FPG3 provides Similar information to the OGTT. FPG concentrations of 6.0 and 7.1 were found equivalent to the 1985 World Health Organization OGTT thresholds for impaired glucose tolerance and diabetes (7.8 and 11.1 mmol/l).