Coordinate inhibition of plasminogen activator and tumor growth by hydrocortisone in mouse mammary carcinoma.
Coordinate inhibition of plasminogen activator and tumor growth by hydrocortisone in mouse mammary carcinoma.
复制标题
氢化可的松在小鼠乳腺癌中协调抑制纤溶酶原激活剂和肿瘤生长。
作者：
R. Mira‐Y‐Lopez;E. Reich;R. Stolfi;D. Martin;L. Ossowski
大量证据表明，调节体外培养的肿瘤外植体的纤溶酶原激活物产生的激素可能对体内相同肿瘤的生长具有定性上相当的影响。作为对这种相关性的测试并探索其预测肿瘤对激素的体内反应的潜力，我们在这里研究了氢化可的松对小鼠乳腺肿瘤病毒确定的乳腺肿瘤的原代和第一代移植物生长的影响。在BALB/c X DBA/8 F1中（下文称为CD 8 F1）小鼠;先前已发现氢化可的松抑制这些肿瘤的外植体产生纤溶酶原激活物。结果是：（a）氢化可的松可逆地阻断了可触知的原发性肿瘤的生长;在撤除外源激素后，生长以对照速率恢复;（B）当在可触知的肿瘤出现之前或之后给药时，氢化可的松抑制了第一代肿瘤移植物的生长;（c）用氢化可的松预处理既延迟了原发性肿瘤的出现，又大大降低了易感小鼠中的肿瘤发生率;肿瘤发生率的大部分降低显然是不可逆的;（d）氢化可的松减少肿瘤生长伴随着抑制肿瘤纤溶酶原激活物含量，并且这些作用显示出类似的剂量依赖性（通过125 I-纤维蛋白平板测定法测量肿瘤裂解物的酶含量）;在对照组和经顺铂处理的肿瘤中存在的酶主要是尿激酶型。这些研究结果表明，纤溶酶原激活剂的生产和乳腺肿瘤生长在CD 8 F1小鼠协调调节，从而鼓励认为，纤溶酶原激活剂可能是有用的，作为一种体外标记物，用于预测在体内肿瘤激素的反应。
A body of evidence has suggested that hormones which modulate plasminogen activator production by cultured tumor explants in vitro may have a qualitatively comparable effect on the growth of the same tumors in vivo. As a test of this correlation and to explore its potential for predicting the in vivo response of tumors to hormones, we have studied here the effect of hydrocortisone on the growth of primary and first generation transplants of mouse mammary tumor virus-determined mammary tumors in BALB/c X DBA/8 F1 (hereafter called CD8F1) mice; hydrocortisone had been found previously to inhibit plasminogen activator production by explants of these tumors. The results were: (a) hydrocortisone reversibly blocked the growth of palpable primary tumors; growth resumed at control rates following withdrawal of exogenous hormone; (b) hydrocortisone inhibited the growth of first-generation tumor transplants when administered either before or after the appearance of palpable tumors; (c) pretreatment with hydrocortisone both delayed the appearance of primary tumors and greatly reduced tumor incidence in susceptible mice; a substantial part of the decrease in tumor incidence was apparently irreversible; (d) hydrocortisone reduction of tumor growth was accompanied by inhibition of tumor plasminogen activator content, and these effects displayed a similar dose dependence (enzyme content of tumor lysates was measured by the 125I-fibrin plate assay); the enzyme present in control and hormone-treated tumors was predominantly of the urokinase type. These findings suggest that plasminogen activator production and mammary tumor growth in CD8F1 mice are coordinately regulated and thus encourage the view that plasminogen activator might be useful as an in vitro marker for predicting the in vivo response of tumors to hormones.
类固醇刺激人乳腺癌细胞系 (MCF-7) 中纤溶酶原激活剂的产生。
影响因子：
11.2
作者：
Butler,WB;Kirkland,WL;Gargala,TL;Goran,N;Kelsey,WH;Berlinski,PJ
通讯作者：
Berlinski,PJ
地塞米松诱导的肝癌细胞纤溶活性抑制剂。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Coleman,PL;Barouski,PA;Gelehrter,TD
通讯作者：
Gelehrter,TD