Two artificial tears outbreak-associated cases of XDR Pseudomonas aeruginosa detected through whole genome sequencing-based surveillance.
Two artificial tears outbreak-associated cases of XDR Pseudomonas aeruginosa detected through whole genome sequencing-based surveillance.
复制标题
通过基于全基因组测序的监测发现了两例与人工泪液爆发相关的 XDR 铜绿假单胞菌病例。
DOI：
10.1101/2023.04.11.23288417
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
VanTyne,Daria
中科院分区：
文献类型：
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作者：
Sundermann,AlexanderJ;Srinivasa,VatsalaRangachar;Mills,EmmaG;Griffith,MarissaP;Waggle,KadyD;Ayres,AshleyM;Pless,Lora;Snyder,GrahamM;Harrison,LeeH;VanTyne,Daria
我们描述了两例XDR铜绿假单胞菌感染病例，该感染是由最近与全国范围内受污染的人工泪液爆发相关的公共卫生问题菌株引起的。这两例病例都是通过医院相关传播增强检测系统（EDS-HAT）中的基因组数据库审查检测到的，这是一项基于常规基因组测序的监测计划。我们从我们中心的一个病例分离株中生成了爆发菌株的高质量参考基因组，并检查了编码blaVIM-80和blaGES-9碳青霉烯酶的移动的元件。然后，我们使用公开的铜绿假单胞菌基因组来探索爆发菌株的遗传相关性和抗菌素耐药基因。
We describe two cases of XDR Pseudomonas aeruginosa infection caused by a strain of public health concern recently associated with a nationwide outbreak of contaminated artificial tears. Both cases were detected through database review of genomes in the Enhanced Detection System for Hospital-Associated Transmission (EDS-HAT), a routine genome sequencing-based surveillance program. We generated a high-quality reference genome for the outbreak strain from one of the case isolates from our center and examined the mobile elements encoding blaVIM-80 and blaGES-9 carbapenemases. We then used publicly available P. aeruginosa genomes to explore the genetic relatedness and antimicrobial resistance genes of the outbreak strain.