Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats
Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats
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DOI：
10.1016/s0197-4580(00)00103-2
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发表时间：
2000-01-01
影响因子：
4.2
通讯作者：
Gibbs, RB
中科院分区：
文献类型：
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作者：
Gibbs, RB
雌性Sprague-Dawley大鼠在13月龄时切除卵巢。四组患者在卵巢切除术后立即、3个月或10个月开始接受不同的雌激素或雌激素加孕激素替代方案，并与非激素治疗的对照组进行比较。卵巢切除术后8至12个月，动物接受延迟位置匹配（delayed matching to position，ESTA）空间记忆任务的训练。雌激素或雌激素加孕激素的长期治疗显著增强了长期卵巢功能丧失后的老年动物的卵巢功能。每周给予雌激素和孕激素至少与单独使用雌激素的连续治疗一样有效，如果不是更有效的话。此外，在卵巢切除术后3个月开始治疗，而不是10个月，在增强认知功能方面与卵巢切除术后立即开始的持续雌激素治疗一样有效，这表明卵巢功能丧失后有一个机会窗口，在此期间，激素替代可以有效地防止衰老和激素剥夺对认知功能的影响。这些研究结果表明，在卵巢功能丧失后的特定时间内开始重复使用雌激素和孕激素治疗可能有效地预防激素剥夺对大脑衰老和认知能力下降的特定负面影响。(C)2000 Elsevier Science Inc. All rights reserved.
Female Sprague-Dawley rats were ovariectomized at 13 months of age. Four groups received different regimens of estrogen or estrogen plus progesterone replacement beginning either immediately, 3 months, or 10 months after ovariectomy and were compared with non-hormone-treated controls. Eight to twelve months after ovariectomy, animals were trained on a delayed matching-to-position (DMP) spatial memory task. Long-term treatment with estrogen or estrogen plus progesterone significantly enhanced acquisition of the DMP task aged animals after long-term loss of ovarian function. Weekly administration of estrogen and progesterone was at least as effective as, if not more effective than, continuous treatment with estrogen alone. In addition, treatment initiated 3 months, but not 10 months, after ovariectomy was as effective at enhancing DMP acquisition as continuous estrogen treatment initiated immediately after ovariectomy, suggesting a window of opportunity after the loss of ovarian function during which hormone replacement can effectively prevent the effects of aging and hormone deprivation on cognitive function. These findings suggest that repeated treatment with estrogen and progesterone initiated within a specific period of time after the loss of ovarian function may be effective at preventing specific negative effects of hormone deprivation on brain aging and cognitive decline. (C) 2000 Elsevier Science Inc. All rights reserved.