An ultrastructural description of glutamate-like immunoreactivity in the rat cerebellar cortex.
An ultrastructural description of glutamate-like immunoreactivity in the rat cerebellar cortex.
复制标题
大鼠小脑皮质中谷氨酸样免疫反应性的超微结构描述。
DOI：
10.1016/0006-8993(87)91304-7
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Beitz,AJ
中科院分区：
文献类型：
--
作者：
Clements,JR;Monaghan,PL;Beitz,AJ
本研究提供了第一个超微结构的描述谷氨酸样免疫反应神经元和过程中的小脑皮质的大鼠。谷氨酸样免疫反应见于平行纤维、颗粒细胞胞体、浦肯野细胞树突和苔藓状纤维肾小球。这些数据支持了先前的研究，这些研究表明颗粒细胞可能使用谷氨酸作为神经递质。然而，并非所有的颗粒细胞或所有的平行纤维谷氨酸样免疫反应，这表明一些颗粒细胞可能使用谷氨酸以外的递质。苔藓纤维中谷氨酸样免疫反应的存在支持了一些小脑传入系统可能使用谷氨酸作为神经递质的假设。
This study provides the first ultrastructural description of glutamate-like immunoreactive neurons and processes in the cerebellar cortex of the rat. Glutamate-like immunoreactivity was seen in parallel fibers, granule cell perikarya, Purkinje cell dendrites, and mossy fiber glomeruli. These data support previous studies that have suggested that granule cells may use glutamate as a neurotransmitter. However, not all granule cells or all parallel fibers were glutamate-like immunoreactive, suggesting that some granule cells may use transmitters other than glutamate. The presence of glutamate-like immunoreactivity in mossy fibers supports the hypothesis that some cerebellar afferent systems may use glutamate as a neurotransmitter.