Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth
Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth
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DOI：
10.1371/journal.pone.0219637
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发表时间：
2019-10-23
期刊：
影响因子：
3.7
通讯作者：
Fisher, Matthew B.
中科院分区：
文献类型：
--
作者：
Cone, Stephanie G.;Piercy, Hope E.;Fisher, Matthew B.
先前的研究分析了物种之间或身体各节段之间肌肉骨骼组织的生长；然而，很少有研究评估单个关节内类似组织的差异。本研究通过高场磁共振成像技术，研究了母羊约克猪胫股关节四种韧带和肌腱（前交叉韧带、髌骨肌腱、内侧副韧带、外侧副韧带）在生长过程中长度和截面积的变化。从出生到青春期晚期，组织长度增加了4- 5倍，组织横截面积增加了10-20倍。前交叉韧带和外侧副韧带呈异速生长，长度变化大于截面积变化，而髌腱和内侧副韧带呈等距生长。此外，前交叉韧带的长度和横截面积的变化没有其他韧带和肌腱的变化那么大。总的来说，这些发现表明，在产后生长过程中，肌肉骨骼软组织形态测量可以在相似结构的组织内和单个关节内发生变化。
Prior studies have analyzed growth of musculoskeletal tissues between species or across body segments; however, little research has assessed the differences in similar tissues within a single joint. Here we studied changes in the length and cross-sectional area of four ligaments and tendons, (anterior cruciate ligament, patellar tendon, medial collateral ligament, lateral collateral ligament) in the tibiofemoral joint of female Yorkshire pigs through high-field magnetic resonance imaging throughout growth. Tissue lengths increased by 4-to 5-fold from birth to late adolescence across the tissues while tissue cross-sectional area increased by 10-20-fold. The anterior cruciate ligament and lateral collateral ligament showed allometric growth favoring change in length over change in cross-sectional area while the patellar tendon and medial collateral ligament grow in an isometric manner. Additionally, changes in the length and cross-sectional area of the anterior cruciate ligament did not increase as much as in the other ligaments and tendon of interest. Overall, these findings suggest that musculoskeletal soft tissue morphometry can vary within tissues of similar structure and within a single joint during post-natal growth.