Age-related Decrease of Sirtuin 2 Protein in Human Peripheral Blood Mononuclear Cells.
Age-related Decrease of Sirtuin 2 Protein in Human Peripheral Blood Mononuclear Cells.
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DOI：
10.2174/1874609808999150831112939
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发表时间：
2015-10
影响因子：
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通讯作者：
K. Yudoh;R. Karasawa;Junji Ishikawa
中科院分区：
文献类型：
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作者：
K. Yudoh;R. Karasawa;Junji Ishikawa
Sirtuin 2主要存在于细胞质中，在哺乳动物发育、热量限制、代谢调节、细胞抗氧化潜能和衰老调节等方面发挥着重要作用。我们发现人类外周血单个核细胞（pbmc）中sirtuin 2蛋白水平随着供体年龄的增加而降低。我们的数据表明，在男性和女性中，pbmc中的sirtuin 2水平随着年龄的增长而下降，可能有潜力作为监测健康状况和衰老的有用生物标志物。
Sirtuin 2, which is mainly present in cytoplasm, plays an important role in mammalian development, caloric restriction, metabolic regulation cellular antioxidant potential and the regulation of aging. We found that the protein level of sirtuin 2 in human peripheral blood mononuclear cells (PBMCs) decreases with an advance in donor age in men and women. Our data suggest that sirtuin 2 level in PBMCs decreases with age in both men and women and may have a potential as a useful biomarker monitoring health conditions and aging.