Gastrointestinal myoelectrical activity in idiopathic intestinal pseudo-obstruction.
Gastrointestinal myoelectrical activity in idiopathic intestinal pseudo-obstruction.
复制标题
特发性假性肠梗阻中的胃肠肌电活动。
DOI：
--
复制
发表时间：
1977
影响因子：
158.5
通讯作者：
S. Cohen
中科院分区：
文献类型：
--
作者：
M. Sullivan;W. Snape;S. A. Matarazzo;R. Petrokubi;G. Jeffries;S. Cohen
我们评估了四名慢性特发性假性肠梗阻患者的食管、小肠、结肠和肛门括约肌的肌电和运动功能。所有患者均有食管闭锁，吞咽或球囊扩张后食管下括约肌松弛不完全。十二指肠慢波频率正常，为11.4+/-0.3（+/-S.E.M.）每分钟循环数。患者在肠扩张后十二指肠峰电位或运动活动没有正常增加，但在静脉注射促胰液素刺激后十二指肠活动增加。结肠慢波活动存在两种频率，6.2+/-0.3和3.3+/-0.1周期/分钟。新斯的明给药增加结肠峰电位和运动活动正常。这些研究表明，在这种疾病中，吞咽或肠扩张的生理神经反应受损，但肠平滑肌慢波活动和尖峰和运动反应外源性神经激素刺激是完整的。
We evaluated the myoelectrical and motor function of the esophagus, small intestine, colon and anal sphincter in four patients with chronic idiopathic intestinal pseudo-obstruction. All patients had aperistalsis of the esophagus, with incomplete relaxation of the lower esophageal sphincter after swallowing or balloon distension. Duodenal slow-wave frequency was normal at 11.4+/-0.3 (+/-S.E.M.) cycles per minute. The patients did not have a normal increase in duodenal spike or motor activity after intestinal distension, but duodenal activity increased after stimulation with intravenous secretin. Colonic slow-wave activities were present at two frequencies, 6.2+/-0.3 and 3.3+/-0.1 cycles per minute. Neostigmine administration increased both colonic spike and motor activity normally. These studies suggest that in this disorder, physiologic neural responses to swallowing or intestinal distension are impaired but the intestinal smooth-muscle slow-wave activity and the spike and motor responses to exogenous neurohormonal stimulation are intact.