Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice
Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice
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DOI：
10.1016/j.fct.2004.08.018
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发表时间：
2005-01-01
影响因子：
4.3
通讯作者：
Park, KK
中科院分区：
文献类型：
--
作者：
Kim, SH;Hong, KO;Park, KK
顺铂是一种广泛使用的抗癌药物，但它会产生不良的副作用，如肾毒性。本文研究了从姜黄中分离得到的黄菌素的药理作用。（姜黄科）对顺铂所致小鼠肾毒性的影响。单剂量顺铂（45mg/kg, i.p）显著升高血尿素氮水平、血清肌酐水平和肾体重比，但黄菌根醇（200mg/kg/天，每os）预处理4天显著减弱顺铂引起的肾毒性。黄菌根醇的预防效果优于姜黄素（200mg/kg）。然而，这种作用似乎与黄菌根醇调节转录因子如核因子- kappab （NF-kappaB）和激活蛋白1 （AP-1）的dna结合活性的能力无关。这是首次证实黄菌素对顺铂所致肾毒性的预防作用，这些数据表明黄菌素是治疗顺铂所致肾毒性的一种有前景的方法。(C) 2004 Elsevier Ltd.版权所有。
Cisplatin is a widely used anticancer drug, but it can produce undesirable side effects such as nephrotoxicity. The present study investigated the effect of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) on cisplatin-induced nephrotoxicity in mice. A single dose of cisplatin (45mg/kg, i.p.) significantly elevated the levels of blood urea nitrogen, serum creatinine, and the kidney to body weight ratio, but the pretreatment of xanthorrhizol (200mg/kg/day, per os) for 4 days significantly attenuated the cisplatin-induced nephrotoxicity. The preventive effect of xanthorrhizol was more efficacious than that of curcumin with the same amount (200mg/kg). However, this effect seemed not to be related with the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1). This is first time the preventive effect of xanthorrhizol on cisplatin-induced nephrotoxicity has been demonstrated, and these data suggest that the administration of xanthorrhizol is a promising approach in the treatment of nephrotoxicity caused by cisplatin. (C) 2004 Elsevier Ltd. All rights reserved.