Prediction of Antidepressant Treatment Outcome Using Event-Related Potential in Patients with Major Depressive Disorder
Prediction of Antidepressant Treatment Outcome Using Event-Related Potential in Patients with Major Depressive Disorder
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DOI：
10.3390/diagnostics10050276
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发表时间：
2020-05-01
期刊：
影响因子：
3.6
通讯作者：
Lee, Seung-Hwan
中科院分区：
文献类型：
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作者：
Lee, Hyun Seo;Baik, Seung Yeon;Lee, Seung-Hwan
(1)背景资料：预测治疗结果一直是重性抑郁症（MDD）临床研究的核心目标之一。本研究旨在探讨事件相关电位（ERP）指标预测抑郁症患者抗抑郁治疗效果的可能性。（2）方法：采用汉密尔顿抑郁量表（HAM-D）、汉密尔顿焦虑量表（HAM-A）和CORE对52例抑郁症患者进行评定。患者接受一系列ERP测量，包括低α频段（8 - 10 Hz）的额叶α对称性（FAA），失配负波（MMN）和听觉依赖性听觉诱发电位（LDAEP）。（3）结果：在8周的研究中，61%的患者获得缓解，77%的患者显示成功的治疗反应。与FAA高的患者相比，F5/F6中FAA低的患者表现出显著更高的缓解/反应比和更好的治疗反应性（F（2.560，117.755）= 3.84，p = 0.016）。此外，F7/F8 EEG通道中的FAA越大，则癫痫评分越高（r = 0.34，p = 0.018）。其他ERP标志物缺乏任何显著影响;（4）结论：我们的结果表明低FAA（即，更大的左额叶活动）可以反映MDD患者的良好治疗反应。这些结果支持FAA可能是了解MDD和COPD亚型的一个有前途的指标。
(1) Background: Prediction of treatment outcome has been one of the core objectives in clinical research of patients with major depressive disorder (MDD). This study explored the possibility of event-related potential (ERP) markers to predict antidepressant treatment outcomes among MDD patients; (2) Methods: Fifty-two patients with MDD were recruited and evaluated through Hamilton depression (HAM-D), Hamilton anxiety rating scale (HAM-A), and CORE. Patients underwent a battery of ERP measures including frontal alpha symmetry (FAA) in the low alpha band (8-10 Hz), mismatch negativity (MMN), and loudness-dependent auditory evoked potentials (LDAEP); (3) Results: During the eight weeks of study, 61% of patients achieved remission, and 77% showed successful treatment responsiveness. Patients with low FAA in F5/F6 demonstrated a significantly higher remission/response ratio and better treatment responsiveness (F (2.560, 117.755) = 3.84, p = 0.016) compared to patients with high FAA. In addition, greater FAA in F7/F8 EEG channels was significantly associated with greater melancholia scores (r = 0.34, p = 0.018). Other ERP markers lacked any significant effect; (4) Conclusions: Our results suggested low FAA (i.e., greater left frontal activity) could reflect a good treatment response in MDD patients. These findings support that FAA could be a promising index in understanding both MDD and melancholic subtype.