5-(2-Aminopropyl)benzofuran and phenazepam demonstrate the possibility of dependence by increasing dopamine levels in the brain
5-(2-Aminopropyl)benzofuran and phenazepam demonstrate the possibility of dependence by increasing dopamine levels in the brain
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DOI：
10.1016/j.pbb.2016.08.002
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发表时间：
2016-10-01
影响因子：
3.6
通讯作者：
Kim, Hyung Soo
中科院分区：
文献类型：
--
作者：
Cha, Hye Jin;Lee, Kwang-Wook;Kim, Hyung Soo
虽然5-（2-氨基丙基）苯并呋喃（5- apb）和7-溴-5-（2-氯苯乙）-1,3-二氢- 2h -1,4苯并二氮平-2-酮（苯那西泮）被用作娱乐性药物，但对它们的依赖性或作用机制的研究尚缺乏。本研究旨在利用条件位置偏好和自我给药范式评价这些药物的行为效应和依赖倾向。此外，生化技术用于评估物质诱导的突触释放多巴胺的改变。虽然这两种被测物质都能引起条件位置偏好和多巴胺的增加，但它们都不能促进自我给药，这表明5-APB和非那西泮具有奖励作用，而不是强化作用。(C) 2016 Elsevier Inc.版权所有。
Although 5-(2-aminopropyl)benzofuran (5-APB) and 7-bromo-5-(2-chlorophenyI)-1,3-dihydro-2H-1,4benzodiazepin-2-one (phenazepam) are being used as recreational drugs, research on their dependence liability or mechanisms of action is lacking. The present study aimed to evaluate the behavioral effects and dependence liability of these drugs using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques were used to assess the substance-induced alterations in synaptosomereleased dopamine. While both of the tested substances elicited increases in conditioned place preference and dopamine, neither of them facilitated self-administration, suggesting that 5-APB and phenazepam have rewarding effects, rather than reinforcing effects. (C) 2016 Elsevier Inc. All rights reserved.