Dual-encapsulated biodegradable 3D scaffold from liposome and waterborne polyurethane for local drug control release in breast cancer therapy
Dual-encapsulated biodegradable 3D scaffold from liposome and waterborne polyurethane for local drug control release in breast cancer therapy
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由脂质体和水性聚氨酯制成的双封装可生物降解 3D 支架，用于乳腺癌治疗中的局部药物控制释放
DOI：
10.1080/09205063.2020.1796230
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tan Hong
中科院分区：
文献类型：
--
作者：
Yin Hang;Du Bohong;Chen Yue;Song Nijia;Li Zhen;Li Jiehua;Luo Feng;Tan Hong
摘要与传统的注射化疗相比，病灶局部释药治疗实体瘤是一种更有效、危害更小的治疗方法。然而，选择合适的药物载体和化疗药物的控释仍然是很大的挑战。本文通过冷冻干燥法制备了紫杉醇(PTX)磷脂脂质体与水性聚氨酯(PU)共混物，设计了一种用于局部药物释放的双囊化三维支架材料。紫杉醇的控释是通过两个同步程序进行的。首先，包裹在聚氨酯支架中的脂质体可以通过对水分的吸收和降解而缓慢释放。然后，紫杉醇包裹在脂质体中也可以释放到水中。与直接包裹紫杉醇的聚氨酯支架相比，双胶囊支架具有较慢的初始释放量和较高的后期紫杉醇浓度。而且，磷脂层的保护可以防止紫杉醇被快速分解和清除，大大提高了紫杉醇的生物利用度和治疗效果。细胞实验结果表明，双囊化支架不仅对乳腺癌MCF7细胞有较高的抑制率，而且对正常组织细胞的损伤较小。为肿瘤的局部药物治疗提供了更有效的平台。
Abstract Compared with the traditional chemotherapy by injection, local release of drugs in the lesion area is a more efficient and less harmful treatment for solid tumors. However, the selection of appropriate drug carrier and controlled release of chemotherapy drugs are still great challenges. Herein, a kind of dual-encapsulated three-dimensional (3D) scaffold is designed for local drug release via blending the paclitaxel (PTX) loaded phospholipid liposomes with waterborne polyurethane (PU) by freeze-drying. The controlled release of paclitaxel is carried out through two simultaneous procedures. First, liposomes encapsulated in polyurethane scaffold can slowly release by water absorption and degradation of polyurethane. Then paclitaxel encapsulated in liposomes can also be released into water. Compared with the polyurethane scaffold which directly encapsulated paclitaxel, dual-encapsulated scaffold has slower initial release amount and maintain higher concentration of paclitaxel in later stage. Moreover, the protection of the phospholipid layer can prevent paclitaxel from being quickly decomposed and cleared, which could greatly improve the bioavailability and therapeutic effect of paclitaxel. Cell experiment results can be seen that dual-encapsulated scaffold not only has higher inhibition rate to the breast cancer MCF7 cells, but also has less damage to normal tissue cells. It provides a more effective platform for the local drug therapy in the treatment of tumors.