Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine
Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine
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DOI：
10.1271/bbb.63.1295
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发表时间：
1999-07-01
影响因子：
1.6
通讯作者：
Kono, Y
中科院分区：
文献类型：
--
作者：
Shibata, H;Sakamoto, Y;Kono, Y
绿原酸阻止了 3 mM 一氯胺诱导的质粒 pUC18 DNA 的逐步转化，I 型-->II 型-->III 型，半抑制率为 67.4 muM。绿原酸与一氯胺的反应呈时间依赖性，反应速率随着 pH 值的降低而增加。这些结果表明绿原酸可以防止一氯胺在胃粘膜中的遗传毒性。
Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 mu M. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.