Summary of the IVth International Sjögren's Syndrome Meeting.
Summary of the IVth International Sjögren's Syndrome Meeting.
复制标题
第四届国际干燥综合症会议摘要。
DOI：
10.1002/art.1780370523
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发表时间：
1994
影响因子：
--
通讯作者：
I. Saito
中科院分区：
文献类型：
--
作者：
R. Fox;I. Saito
在本间三夫教授的指导下，第四届国际干燥综合征会议于1993年8月11-13日在东京举行。临床会议致力于干眼和口干的分类和治疗；基础研究会议侧重于耐受机制、遗传和环境辅助因素以及细胞因子和神经内分泌机制的失败。最近发表的欧洲合作研究小组关于干燥综合征分类的初步标准(1)引起了广泛的讨论。争论的关键点是，在没有自身抗体或嘴唇唾液腺活检结果阳性的情况下，这些标准可以满足。几组调查人员表示担心，标准过于模糊，被归类为干燥综合征的患者群体过于多样化，无法作为流行病学或临床研究的基础。临床研究的一个令人惊讶的方面是，口腔干燥的症状与唾液量的相关性很小，这表明特定的蛋白质和粘蛋白在维持粘膜表面完整性和不适症状中发挥了作用。目前正在进行生化研究，以确定负责维持角膜/结膜分化的特定粘蛋白(糖蛋白)、黏附分子(整合素、选择素、钙粘附素)和低分子蛋白质(防御素、组他汀类)的特征。
Under the direction of Professor Mitsuo Homma, the IVth International Sjogren’s Syndrome Meeting was held August 11-13, 1993 in Tokyo. Clinical sessions were devoted to classification and treatment of dry eyes and dry mouth; basic research sessions focused on the failure of tolerance mechanisms, genetic and environmental cofactors, and cytokine and neuroendocrine mechanisms. The recently published European Cooperative Study Group preliminary criteria for the classification of Sjogren’s syndrome (1) generated extensive discussion. The key point of debate was that these criteria could be fulfilled in the absence of either autoantibodies or positive findings on labial salivary gland biopsy. Several groups of investigators expressed concern that the criteria were too vague and that the group of patients classified as having Sjogren’s syndrome would be too heterogeneous to serve as a basis for epidemiologic or clinical studies. A surprising aspect of clinical studies was that symptoms of oral dryness correlated poorly with volume of saliva, suggesting a role for specific proteins and mucins in the maintainence of mucosal surface integrity and in symptoms of discomfort. Biochemical studies are underway to characterize the specific mucins (glycoproteins), adhesive molecules (integrins, selectins, cadherins), and low molecular weight proteins (defensins, histatins) that are responsible for maintaining the differentiation of the corneal/conjunc-