BIOSYNTHESIS OF CEPHALOSPORIN C
BIOSYNTHESIS OF CEPHALOSPORIN C
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DOI：
10.1128/aem.10.4.321-325.1962
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发表时间：
1962-01-01
期刊：
影响因子：
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通讯作者：
NEWKIRK, JF
中科院分区：
文献类型：
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作者：
DEMAIN, AL;NEWKIRK, JF
证实了D-甲硫氨酸在粗培养基中刺激头孢菌素C合成方面优于L-甲硫氨酸。DL-蛋氨酸的最佳添加量为0.5%。甲硫氨酸轻微刺激生长，但这并不被认为是显着刺激抗生素合成的原因。在大量的硫化合物中，只有DL-蛋氨酸-DL-亚砜和S-甲基-L-半胱氨酸显示出相当大的蛋氨酸替代活性。赖氨酸和[α]-氨基己二酸无活性。
The superiority of D-Methionine over L-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of DL-methionine was 0.5%. Methionine stimulates growth slightly, but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested only DL-methionine-DL-sulfoxide and S-methyl-L-cysteine showed considerable methionine-replacing activity. Lysine and [alpha]-aminoadipic acid were inactive.