Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age
Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age
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DOI：
10.1016/j.neurobiolaging.2007.05.013
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Bastin, Mark E.;Clayden, Jonathan D.;Deary, Ian J.
弥漫性脑室周围白质高信号区域（PVWMH）是老年人T(2)加权MRI扫描的常见发现，但其活性尚不清楚。本研究的目的是表征宏观上看起来正常的白质（NAWM）和PVWMH之间的水扩散和磁化转移MRI参数的差异。42名83岁非痴呆患者接受了结构、扩散张量和磁化转移MRI检查。平均扩散系数（< D >），分数各向异性（FA）。测量NAWM和PVWMH在额部、顶枕白质和半瓣中央的轴向（lambda(ax)）和径向（lambda(rad)）扩散率和磁化传递比（MTR）。PVWMH三个区域的< D >、λ (ax)和λ (rad)均高于NAWM， FA和MTR均显著低于正常组织(p
Regions of diffuse periventricular white matter hyperintensities (PVWMH) are a common finding on T(2)-weighted MRI scans of older subjects, but their actiology remains unclear. The aim of this study was to characterize differences in water diffusion and magnetization transfer MRI parameters between macroscopically normal-appearing white matter (NAWM) and PVWMH in a cohort of normal older subjects. Forty-two non-demented 83-year olds underwent structural, diffusion tensor and magnetization transfer MRI. Mean diffusivity (< D >), fractional anisotropy (FA). axial (lambda(ax)) and radial (lambda(rad)) diffusivity, and magnetization transfer ratio (MTR) were measured in both NAWM and PVWMH in frontal and parieto-occipital white matter, and centrum semiovale. For all three regions, PVWMH had greater < D >, lambda(ax) and lambda(rad) than NAWM, while FA and MTR wcre significantly reduced compared with normal tissue (p